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Copyright ©The Author(s) 2019.
World J Gastroenterol. Nov 28, 2019; 25(44): 6483-6494
Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6483
Table 1 Functions of inositol 1,4,5-trisphosphate receptor isoforms in hepatocytes and cholangiocytes
ITPR isoformCell typeFunctionRef.
ITPR1HepatocytesGlucose secretion[64]
Lipid metabolism[63,65]
Liver regeneration[66,67]
CholangiocytesBicarbonate secretion[12,61]
ITPR2HepatocytesOrganic anion secretion[6,62,69]
Liver regeneration[13,71]
Cholangiocytesbicarbonate secretion[12,61]
ITPR3HepatocytesPhysiologically absent[6]
Proliferation and survival of hepatocellular carcinoma[74]
CholangiocytesBicarbonate secretion[12,61]
Proliferation, migration, and survival of cholangiocarcinoma[82]