Serum amyloid A levels in patients with liver diseases

doi:10.3748/wjg.v25.i43.6440

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 43

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6798)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-5) series.

Item

Count

PDF

412

WORD

205

HTML

3365

Figures (1-1)

192

Tables (1-5)

144

Sum=4318

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

900

Download

1580

Sum=2480

Nov 21, 2019 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (19)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Nov 21, 2019; 25(43): 6440-6450
Published online Nov 21, 2019. doi: 10.3748/wjg.v25.i43.6440

Table 1 Serum levels of serum amyloid A in different groups of subjects

Subjects (n)	mean ± SD, (mg/L)	Median (minimum-maximum), (mg/L)	Z¹ (compared with healthy controls/active CHB)	P¹ (compared with healthy controls/ active CHB)
Healthy controls (117)	2.902 ± 1.801	2.250 (0.797-9.040)	-	-
Inactive CHB (146)	2.936 ± 3.092	2.350 (0.800-29.90)	-1.129/-7.281	0.259/< 0.001
Active CHB (59)	6.621 ± 6.776	4.000 (1.700-39.90)	-5.980	< 0.001
NASH (21)	6.624 ± 4.891	5.500 (2.800-23.00)	-4.867	< 0.001
Drug-induced liver injury (14)	8.036 ± 5.685	6.800 (3.400-26.20)	-4.992	< 0.001
Autoimmune liver disease (22)	19.73 ± 24.81	13.70 (3.300-108.0)	-6.870	< 0.001
Pyogenic liver abscess (16)	398.4 ± 246.8	413.5 (62.20-871.0)	-6.474	< 0.001

¹Mann-Whitney U test was used to compare the serum amyloid A levels between various liver disease groups and the healthy control group, and Bonferroni test was applied for post hoc comparisons to control the probability of type 1 error (alpha = 0.05/6 = 0.008). CHB: Chronic hepatitis B; NASH: Nonalcoholic steatohepatitis.

Table 2 Single factor analysis of serum levels of serum amyloid A in patients with chronic hepatitis B

Factor	SAA < 6.4 mg/L	SAA ≥ 6.4 mg/L	χ²/t value¹	P¹ value	OR (95%CI)
Factor	Positive cases/total cases (%)	Positive cases/total cases (%)	χ²/t value¹	P¹ value	OR (95%CI)
Female	39/182 (21.4%)	6/23 (26.1%)	0.259	0.611	1.294 (0.478-3.503)
Age (yr)	47.87 ± 13.17	49.26 ± 14.476	-0.471	0.638	-
ALT ≥ 40 U/L	53/178 (29.8%)	7/22 (31.8%)	0.039	0.844	1.101 (0.424-2.854)
AST ≥ 35 U/L	68/178 (38.2%)	7/22 (31.8%)	0.340	0.560	0.755 (0.293-1.946)
γ-GT ≥ 45 U/L	60/178 (33.7%)	9/22 (40.9%)	0.449	0.503	1.362 (0.551-3.365)
ALP ≥ 135 U/L	12/179 (6.70%)	5/22 (22.7%)	4.592	*0.032*	4.093 (1.288-13.011)
Elevated ALP or γ-GT level	63/178 (35.4%)	10/22 (45.5%)	0.855	0.355	1.521 (0.622-3.718)
AFP ≥ 20 ng/mL	16/173 (9.2%)	3/22 (13.6%)	0.074	0.786	1.549 (0.413-5.810)
A/G ≤ 1.2	32/177 (18.1%)	7/22 (31.8%)	1.553	0.213	2.115 (0.797-5.608)
Active CHB	44/182 (24.2%)	15/23 (65.2%)	16.78	< 0.001	5.881 (2.337-14.797)
Child-Pugh grade B or C	19/182 (10.4%)	6/23 (26.1%)	3.322	0.068	1.212 (0.946-1.552)
Complicated by UGIB	5/152 (3.29%)	1/20 (5.00%)	0.000	1.000	1.547 (0.172-13.959)
Complicated by HE	4/152 (2.63%)	1/20 (5.00%)	0.000	1.000	1.947 (0.207-18.343)
Complicated by ascites	19/152 (12.5%)	6/20 (30.0%)	3.062	0.080	3.000 (1.029-8.749)
Complicated by UGIB or HE or ascites	23/152 (15.1%)	6/20 (30.0%)	1.828	0.176	2.404 (0.838-6.898)
Complicated by HCC	28/182 (15.4%)	3/23 (13.0%)	0.000	1.000	0.825 (0.230-2.963)
CRP ≥ 3 mg/L	5/35 (14.3%)	7/7 (100%)	17.01	< 0.001	6.993 (3.106-15.873)
HBsAg	160/168 (95.2%)	20/22 (90.9%)	0.121	0.728	0.500 (0.099-2.521)
HBV DNA ≥ 2000 IU/mL	43/177 (24.3%)	4/21 (19.0%)	0.285	0.593	0.733 (0.234-2.297)
Received antiviral therapy	87/162 (53.7%)	13/22 (59.1%)	0.227	0.634	1.245 (0.504-3.076)

¹Continuous normal distribution data were analyzed by the t-test to determine the difference between two groups. Enumeration data were analyzed by the chi-square test to analyze the difference between groups. ALT: Alanine transaminase; AST: Aspartate transaminase; γ-GT: γ-glutamyltransferase; ALP: Alkaline phosphatase; AFP: Alpha-fetoprotein; A/G: Albumin/globulin ratio; HCC: Hepatocellular carcinoma; CRP: C-reactive protein; UGIB: Upper gastrointestinal bleeding; HE: Hepatic encephalopathy; SAA: Serum amyloid A; CHB: Chronic hepatitis B.

Table 3 Multivariate analysis of serum levels of serum amyloid A in patients with chronic hepatitis B

Factor	Regression coefficient	P value	OR	95%CI
Active CHB	1.828	0.039	6.222	1.095-35.36

CHB: Chronic hepatitis B.

Table 4 Comparison of serum amyloid A levels between active and inactive chronic hepatitis B patients with oral antiviral therapy

Status of patients with antiviral therapy	n	mean ± SD of SAA (mg/L)	Average rank of SAA	Z¹ value	P¹ value
Active CHB	18	6.289 ± 6.042	74.92	-4.077	0.000
Inactive CHB	82	3.379 ± 4.726	44.46	-4.077	0.000

¹The Mann-Whitney U test was used to compare the serum amyloid A levels between various liver disease groups. SAA: Serum amyloid A; CHB: Chronic hepatitis B.

Table 5 Correlation of serum amyloid A and C-reactive protein levels among patients with various liver diseases

Disease	SAA (mg/L)		CRP (mg/L)		¹Spearman’s rank correlation coeffi-cient	P value
Disease	mean ± SD	Median (minimum-maximum)	mean ± SD	Median (minimum-maximum)	¹Spearman’s rank correlation coeffi-cient	P value
CHB	3.984 ± 4.743	3.250 (0.80-39.90)	4.398 ± 6.522	1.500 (0.30-25.40)	0.620	< 0.001
Autoimmune liver disease	19.73 ± 24.81	13.70 (3.30-108.0)	9.633 ± 5.977	9.100 (1.20-19.60)	0.504	0.020
Pyogenic liver abscess	398.4 ± 246.8	413.5 (62.20-871.0)	138.8 ± 57.46	141.1 (22.90-271.3)	0.508	0.045
Drug-induced liver injury	8.036 ± 1.519	6.800 (3.40-26.20)	6.490 ± 2.616	2.850 (0.30-25.30)	0.219	0.544

¹The Spearman’s rank correlation test was used to determine correlation between groups. SAA: Serum amyloid A; CRP: C-reactive protein.

Citation: Yuan ZY, Zhang XX, Wu YJ, Zeng ZP, She WM, Chen SY, Zhang YQ, Guo JS. Serum amyloid A levels in patients with liver diseases. World J Gastroenterol 2019; 25(43): 6440-6450
URL: https://www.wjgnet.com/1007-9327/full/v25/i43/6440.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i43.6440