Observational Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Oct 14, 2019; 25(38): 5883-5896
Published online Oct 14, 2019. doi: 10.3748/wjg.v25.i38.5883
Table 1 Demographic and clinical features of patients
Demographic dataValue
Male/female16/15
Caucasian/sub-Saharan/chinese122/8/1
Age (years: mean ± SD)45.1 ± 10.2
Virological data
HBV-DNA positivity (persistent/fluctuant)228/3
HBV-DNA titters (IU/mL: Mean ± SD)31.4 × 103 ± 3.5 × 104
Clinical data4
Persistently normal/marginally altered AST or ALT18/13
Persistently normal/marginally altered AST25/6
Persistently normal/marginally altered ALT20/11
AST (IU/L: mean ± SD)25.6 ± 9.5
ALT (IU/L: mean ± SD)28.5 ± 14.3
Fibrosis stage (Fibroscan)
F0-F122
F26
Not available3
Table 2 Assignment of risk of hepatocellular carcinoma development associated to each hepatitis B virus genetic variants
HCC riskHBV regionGenetic variant
High
PreS2PreS2 deletions
BCPC1653T, T1753V (A/C/G), A1762T + G1764A
PrecoreG1896A, G1899A
Suspect
PreS1PreS1 deletions
PreS2T53C
BCPC1773T
PrecoreA1846T
CoreC1914G, C2289A
Minor
PreS1T3098C, T3139A
PreS2PreS2 start codon
ST766A, T791A
BCPT1674C, G1727, C1741, C1761, C1766T, T1768A
PrecoreC1858T, G1862T
CoreC1909, A1934T, C2002T, T2003A, C2100A, A2159G, A2189C, A2246C