Integrative analysis of the inverse expression patterns in pancreas development and cancer progression

doi:10.3748/wjg.v25.i32.4727

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Aug 28, 2019; 25(32): 4727-4738
Published online Aug 28, 2019. doi: 10.3748/wjg.v25.i32.4727

Table 1 Information of the pancreatic cancer datasets

Dataset name	TCGA	GSE62452	PACA-AU (ICGC)	PACA-CA (ICGC)	GSE79670	GSE102238
Histological type	PDAC	PDAC	PDAC	PDAC	PDAC	PDAC
Samples	145	69	89	202	50	48
Gender Female, Male	68, 77	31, 38	41, 48	94, 108	19, 31	21, 27
StageI (IA, IB)	3, 9	0, 4	0, 6	0, 11	3, 6	0, 8
StageII (IIA, IIB)	23, 104	10, 36	20, 47	28, 155	4, 31	19, 15
StageIII	3	13	9	5	6	3
StageIV	3	6	7	3	0	3
Platform	RNA-seq	Affymetrix	RNA-seq	RNA-seq	RNA-seq	Agilent

PDAC: Pancreatic adenocarcinoma.

Table 2 17 significant metabolic subpathways in pancreatic cancer

Pathway ID	Pathway name	Ann molecule ratio	Ann bg ratio	P value	FDR
path:00564_1	Glycerophospholipid metabolism	9/378	47/25051	3.03E-08	5.15E-07
path:00330_1	Arginine and proline metabolism	5/378	18/25051	5.55E-06	4.72E-05
path:00020_1	Citrate cycle (TCA cycle)	3/378	9/25051	0.000267613	0.001516472
path:00630_1	Glyoxylate and dicarboxylate metabolism	3/378	11/25051	0.000513985	0.002184435
path:00140_4	Steroid hormone biosynthesis	4/378	32/25051	0.001313707	0.003783719
path:00430_1	Taurine and hypotaurine metabolism	2/378	4/25051	0.00133543	0.003783719
path:00061_3	Fatty acid biosynthesis	2/378	5/25051	0.002203499	0.004682436
path:00650_1	Butanoate metabolism	2/378	5/25051	0.002203499	0.004682436
path:00565_3	Ether lipid metabolism	3/378	21/25051	0.003704522	0.00699743
path:00260_2	Glycine, serine and threonine metabolism	2/378	7/25051	0.004535597	0.007455604
path:00140_7	Steroid hormone biosynthesis	3/378	23/25051	0.004824214	0.007455604
path:00230_1	Purine metabolism	4/378	58/25051	0.011412618	0.016167876
path:00480_1	Glutathione metabolism	3/378	38/25051	0.019466435	0.025456107
path:00230_2	Purine metabolism	3/378	43/25051	0.026957207	0.032733751
path:00071_1	Fatty acid metabolism	2/378	19/25051	0.032785866	0.037157315
path:00240_1	Pyrimidine metabolism	2/378	48/25051	0.163441722	0.17365683
path:00310_1	Lysine degradation	1/378	21/25051	0.27342756	0.27342756

FDR: False discovery rate.

Citation: Zang HL, Huang GM, Ju HY, Tian XF. Integrative analysis of the inverse expression patterns in pancreas development and cancer progression. World J Gastroenterol 2019; 25(32): 4727-4738
URL: https://www.wjgnet.com/1007-9327/full/v25/i32/4727.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i32.4727