Eosinophilic esophagitis: Current concepts in diagnosis and treatment

Table 1 Treatment response in eosinophilic esophagitis[117]

	Spectrum of response
Spectrum of outcomes		Non- response	Response	Complete normalization
	Histology	Persistent eosinophilia ≥ 15 eos/hpf	Reduced eosinophilia 7-14 eos/hpf, 1-6 eos/hpf	Normal biopsy < 1 eos/hpf
	Symptoms	Persistent symptons < 30% decrease in a symptom metric	Decrease eosinophilia 30%-90% decrease in a symptom metric	Symptom resolution > 90% decrease in a symptom metric; EEsAI score < 20
	Endoscopy	Persistent endoscopic findings: < 30% decrease in EREFS	Improved findings: EREFS ≥ 2 but less than baseline	Normal esophagus EREFS < 2

EEsAI: Eosinophilic Esophagitis Symptom Activity Index; eos/hpf: Eosinophils per high-power field; EREFS: Eosinophilic Esophagitis Endoscopic Reference Score.