Meta-Analysis
Copyright ©The Author(s) 2019.
World J Gastroenterol. Jul 21, 2019; 25(27): 3649-3663
Published online Jul 21, 2019. doi: 10.3748/wjg.v25.i27.3649
Table 1 Clinical information and characteristics of included studies
Author (year)CountryControlImmuno-therapy interven-tionsPatients
Child-Pugh score A/B/C
Immune cell regimensCourse
ControlTrialControlTrial
Nakamoto (2007)[19]JapanTACETACE + DC11104/7/08/2/05 × 1061
Nakamoto (2011)[20]JapanTACETACE + DC2213NR5/8/05 × 1061
El Ansary (2013)[21]EgyptSupportive treatmentDC15150/14/10/15/020 × 1061
Sun (2015)[22]ChinaResection + FOLFOX6Resection + DC8080NRNR8.9 × 1096
Lee (2017)[23]South KoreaResection/RFA/PEIResection/RFA/PEI + DC7569NRNR3 × 1076
Weng (2007)[24]ChinaTACE + RFATACE + RFA + CIK404533/7/036/9/01.0-1.5 × 10108/9
Dong (2008)[25]ChinaResectionResection + CIK438434/9/068/16/01.0-2.0 × 10103/5
Hao (2010)[26]ChinaTACETACE + RFA + CIK747266/8/065/7/01.0-5.0 × 10104
Pan (2010)[27]ChinaTACE + RFATACE + RFA + CIK3942NRNR1.0 × 10104
Pan (2013)[28]ChinaResectionResection + CIK206204206/0/0204/0/01.0-1.5 × 10104
Lee (2015)[29]South KoreaResection/RFA/PEIResection/RFA/PEI + CIK112114112/0/0114/0/0NR16
Pan (2015)[30]ChinaResectionResection + CIK520511NRNR1.0-1.5 × 10104
Chen (2016)[31]ChinaResectionResection + CIK118231205/12/0222/9/01.0-1.5 × 10104
Li (2016)[32]ChinaOxaliplatin + CapecitabineCIK373733(A + B)/4(C)27(A + B)/10(C)NRNR
Chang (2018)[33]ChinaResectionResection + CIK145145145/0/0145/0/0NRNR
Lee (2018)[34]South KoreaResection/RFA/PEIResection/RFA/PEI + CIK112114112/0/0114/0/06.4 × 10916
Cui (2014)[35]ChinaRFARFA + NK/γδT/CIK323014/18/018/12/01.2-2.0 × 1098
Qian (2016)[36]ChinaRFARFA + NK/γδT/CIK3173NRNR1.0-2.0 × 1098
Qiu (2011)[37]ChinaResectionResection + DC/CIK99NRNR2.0-20.0 × 109NR
Niu (2013)[38]ChinaCryoablationCytotherapy + DC/CIK1221NRNR6.0-10.0 × 109NR
Shimizu (2014)[39]JapanResectionResection + DC/CIK403544/8/034/8/0NRNR
Yu (2015)[40]ChinaMicrowave ablationMicrowave ablation + DC/CIK151415/0/013/1/0NRNR
Table 2 Quality assessment of randomized controlled trials with Cochrane Collaboration’s tool
Author (year)Selection
Performance
Detection
Attrition
Reporting
Other
BiasBiasBiasBiasBiasBias
El Ansary (2013)UnclearHighUnclearLowLowLow
Sun (2015)UnclearHighUnclearLowLowLow
Dong (2008)UnclearHighUnclearLowLowLow
Lee (2015)UnclearHighUnclearLowLowLow
Lee (2018)UnclearHighUnclearLowLowLow
Qiu (2011)UnclearHighUnclearLowLowLow
Yu (2015)UnclearHighUnclearLowLowLow
Table 3 Quality assessment of non-randomized controlled trials with MINORS
Author (year)123456789101112
Nakamoto (2007)222001202222
Nakamoto (2011)222201202222
Lee (2017)222202022222
Weng (2007)222202202222
Hao (2010)222202222222
Pan (2010)222201202222
Pan (2013)222201202222
Pan (2015)222202202222
Chen (2016)222202202222
Li (2016)222201222222
Chang (2018)222202222222
Cui (2014)222001202222
Qian (2016)222102002222
Niu (2013)222002202222
Shimizu (2014)222002222222