Copyright
©The Author(s) 2019.
World J Gastroenterol. Jul 7, 2019; 25(25): 3151-3167
Published online Jul 7, 2019. doi: 10.3748/wjg.v25.i25.3151
Published online Jul 7, 2019. doi: 10.3748/wjg.v25.i25.3151
Table 1 Homeobox genes show different roles in the progression of hepatocellular carcinoma
| Homeobox genes | Involvement in HCC process | Target genes | Ref. |
| HOXA13 | Colony formation (+), migration (+), Drug resistance (+) | — | [65,67] |
| HOXA7 | Proliferation (-) | Cyclin e1/cdk2 | [68] |
| HOXB7 | Stemness (+), EMT (+) | c-Myc, slug | [69] |
| HMBOX1 | Autophagy (+), Stemness (-), Immunosuppression (-) | PD-L1, Fas | [75] |
| PROX1 | Drug resistance (+), angiogenesis (+) | IL-8, NF-κB, β-catenin | [77-79] |
| NKX3.1 | Proliferation (-) | FOXO1 | [80] |
- Citation: Jiang Y, Han QJ, Zhang J. Hepatocellular carcinoma: Mechanisms of progression and immunotherapy. World J Gastroenterol 2019; 25(25): 3151-3167
- URL: https://www.wjgnet.com/1007-9327/full/v25/i25/3151.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i25.3151