Mini-invasive vs open resection of colorectal cancer and liver metastases: A meta-analysis

Table 1 Characteristics of the included studies

Author-year	Country	Study type	Gender (M/F)		BMI (kg/m2)2		Age (yr)2		Qualityscore3
			MIS	OS	MIS	OS	MIS	OS
Chen-2011	China	Retrospective	18/5	14/4	NR	NR	55 ± 10	53 ± 9	8
Chen-2019	China	Retrospective	10/6	9/13	23.8 ± 3.7	23.3 ± 4.1	66.0 ± 10.4	64.8 ± 13.0	7
Gorgun-2017	America	Retrospective	6/8	16/13	25.1 ± 0.8	27.5 ± 1.2	56.3 ± 3.3	57.7 ± 2.5	7
Hu-2012	China	Matched-pair	10/3	9/4	21.5 ± 7.8	22.2 ± 8.4	54.0 ± 10.0	53.0 ± 11.0	8
Ivanecz-2017	Slovenia	Matched-pair	6/4	6/4	26.9 (23.6-32.1)	24.0 (23.1-25.5)	62.2 ± 7.9	65.4 ± 8.1	9
Lin-2015	China	Matched-pair	5/2	21/15	21.9 ± 2.2	21.2 ± 1.6	59.6 ± 3.4	57.4 ± 10.4	7
Ma-2018	China	Matched-pair	9/3	8/4	23.0 (19.3-26.7)	21.6 (75.5-24.9)	3/91	1/111	8
Ratti-2016	Italy	Matched-pair	14/11	27/23	NR	NR	60 (37-80)	62 (35-81)	8
Takasu-2014	Japan	Matched-pair	3/4	3/4	NR	NR	74.0 ± 12.0	62.0 ± 4.0	7
Tranchart-2016	France	Matched-pair	42/47	40/49	24.0 ± 3.6	24.7 ± 2.5	66.6 ± 10.8	65.0 ± 9.4	7

¹Dichotomous variables, >60/≤60 years;

²The data are expressed as the mean ± SD or medians (range);

³According to the Newcastle-Ottawa scale classification. BMI: Body mass index; F: Female; M: Male; MIS: Minimally invasive surgery; OS: Open surgery; NR: Not reported.

Table 2 Short- and long-term outcomes of the included studies

Author-year	Size of CRC (cm)	TD of CRC W+M/P+O	ID of CRC T1-T2/T3-T4	CRC (C/R)	ASAs 1-2/3-4	CEA level	Number of SCRLM	SCRLM (U/B)	Size of SCRLM (cm)
Chen2011-MIS	2.5 ± 0.9	16/7	NR	3/4	NR	38.9 ± 3.5	NR	NR	5.5 ± 1.2
Chen2011-OS	2.3 ± 1.0	14/4	NR	3/4	NR	38.7 ± 3.3	NR	NR	5.6 ± 1.4
Chen2019-MIS	4.0 ± 2.0	NR	2/14	NR	1.9 (1-3)	929 ± 1936	NR	NR	5.5 ± 4.2
Chen2019-OS	5.0 ± 3.0	NR	2/20	NR	2.0 (1-3)	247 ± 728	NR	NR	4.7 ± 3.7
Gorgun2017-MIS	3.7 ± 0.7	NR	2/12	6/8	0/14	36.9 ± 30.4	1.6 ± 0.3	12/2	2.4 ± 0.7
Gorgun2017-OS	3.7 ± 0.5	NR	7/22	14/15	6/23	14.3 ± 4.9	2.1 ± 0.2	19/10	2.7 ± 0.2
Hu2012-MIS	NR	NR	NR	7/6	NR	NR	NR	NR	3.2 ± 1.0
Hu2012-OS	NR	NR	NR	7/6	NR	NR	NR	NR	3.5 ± 0.9
Ivanecz2017-MIS	NR	10/0	1/9	4/6	8/2	7.7 ± 7.7	1 (1-2)	9/1	2.0 ± 1.2
Ivanecz2017-OS	NR	9/1	1/9	6/4	7/3	15.2 ± 12.5	1 (1-2)	9/1	2.9 ± 1.5
Lin2015-MIS	5.3 ± 1.1	4/3	0/7	3/4	6/1	7/21	1.9 ± 0.9	7/0	3.3 ± 1.8
Lin2015-OS	5.7 ± 1.9	19/17	2/34	19/17	31/5	27/91	2.1 ± 1.0	26/10	4.2 ± 2.2
Ma2018-MIS	NR	10/2	1/11	7/5	12/0	7/52	1.0 (1-4)	10/2	2.8 (0.5-10.0)
Ma2018-OS	NR	9/3	0/12	7/5	12/0	11/12	2.5 (1-7)	7/5	2.5 (1.2-6.5)
Ratti2016-MIS	NR	21/5	NR	13/12	20/5	35.6 (2-299)	2 (1-6)	13/12	2.9 (0.5-11)
Ratti2016-OS	NR	40/10	NR	27/23	44/6	41.6 (3.1-612)	2 (1-7)	27/23	3.4 (0.9-12)
Takasu2014-MIS	4 ± 2	7/0	2/5	3/4	NR	NR	1.4 ± 0.8	5/2	1.9 ± 0.9
Takasu2014-OS	5 ± 0	7/0	1/6	3/4	NR	NR	1.5 ± 1.1	3/4	2.9 ± 1.1
Tranchart2016-MIS	NR	72/17	12/77	48/41	64/25	61 ± 75	1.4 ± 0.6	81/8	2.9 ± 1.9
Tranchart2016-OS	NR	63/26	10/79	51/38	56/33	31 ± 76	1.5 ± 0.7	78/11	2.8 ± 2.0

¹Dichotomous variables, >5/≤5 ng/mL;

²Dichotomous variables, ≥5/<5 ng/mL. B: Bilobar; C: Colon; CRC: Colorectal cancer; ID: Invasion depth; M: Moderate; MIS: Minimally invasive surgery; O: Other; OS: Open surgery; P: Poor; R: Rectal; SCRLM: Synchronous colorectal liver metastases; TD: Tumor differentiation; U: Unilobar; W: Well; NR: Not reported.