Observational Study
Copyright ©The Author(s) 2019.
World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269
Table 1 Demorgraphics, clinical characteristics and psychological states of patients with diarrhea-predominant irritable bowel syndrome and healthy controls
FeatureIBS-D patientsControlsP-value
N3120NA
Age (yr)33.0 (29.0-42.0)28.0 (26.0-36.0)0.056
Gender (male:female)22:0913:070.654
Body mass index (kg/m2)24.2 ± 4.322.2 ± 2.60.095
Duration of disease (yr)5.0 (2.0-10.0)NANA
IBS-SSS274.2 ± 29.8NANA
Severity of abdominal pain1.0 (1.0-2.0)NANA
VSI score54.0 (44.0-61.0)a21.0 (17.3-30.0)< 0.001
HADS anxiety score6.0 (2.0-10.0)a3.0 (1.0-4.0)0.003
HADS depression score4.0 (1.0-8.0)2.5 (1.3-4.0)0.055
Table 2 Correlations between brain-derived neurotrophic factor levels and clinical and experimental parameters in patients with diarrhea-predominant irritable bowel syndrome
BDNF expression
Clinical characteristic
Severity of abdominal pain0.565 (0.001)a
IBS-SSS0.393 (0.029)b
Visceral sensitivity
First sensation threshold-0.562 (0.001)a
Defecating sensation threshold-0.015 (0.938)
Maximum tolerable threshold-0.290 (0.113)
RAIR threshold-0.508 (0.004)a
Mucosal nerve fiber density-0.058 (0.756)
Table 3 Correlations between brain-derived neurotrophic factor level and clinical and experimental parameters in all subjects
BDNF expression
Visceral sensitivity
First sensation threshold-0.557 (< 0.001)a
Defecating sensation threshold-0.196 (0.168)
Maximum tolerable threshold-0.453 (0.001)a
RAIR threshold-0.447 (0.001)a
Mucosal nerve fiber density0.059 (0.681)