Retrospective Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Feb 28, 2018; 24(8): 929-940
Published online Feb 28, 2018. doi: 10.3748/wjg.v24.i8.929
Table 1 Intravoxel incoherent motion diffusion-weighted imaging parameters of different pathologic grades of hepatocellular carcinoma
ParameterObserverEdmondson-Steiner grade
P value
1 (n = 14)2 (n = 24)3 (n = 24)
ADC (× 10-3 mm2/s)1R11.496 ± 0.3121.210 ± 0.1861.003 ± 0.247< 0.001
R21.503 ± 0.3061.214 ± 0.1861.001 ± 0.236< 0.001
D (× 10-3 mm2/s)1R11.186 ± 0.2140.910 ± 0.1510.775 ± 0.188< 0.001
R21.193 ± 0.2260.910 ± 0.1480.771 ± 0.187< 0.001
D* (× 10-3 mm2/s)2R137.400 (43.900)29.000 (71.700)7.980 (63.590)0.057
R232.200 (44.600)28.400 (74.363)7.885 (61.640)0.054
f (%)2R127.250 (14.925)20.675 (11.225)31.300 (12.267)0.149
R226.550 (20.200)21.200 (11.725)31.550 (11.325)0.214
Table 2 Diagnostic value of intravoxel incoherent motion diffusion-weighted imaging and conventional diffusion-weighted imaging parameters in differentiating the low-grade group (G1) from the high-grade groups (G2 and G3)
ParameterObserverAUC (95%CI)Optimal cutoff valueYouden indexSensitivity (%)Specificity (%)Accuracy (%)
ADCR10.843 (0.718, 0.968)1.2850.61978.6(11/14)83.3(40/48)82.3(51/62)
R20.852 (0.730, 0.974)1.2750.64985.7(12/14)79.2(38/48)80.6(50/62)
DR10.909 (0.834, 0.985)0.9620.74192.9(13/14)81.3(39/48)83.9(52/62)
R20.911 (0.832, 0.990)0.9770.80492.9(13/14)87.5(42/48)88.7(55/62)
D*R10.632 (0.489, 0.776)17.750.37885.7(12/14)52.1(25/48)59.7(37/62)
R20.636 (0.495, 0.777)17.900.37885.7(12/14)52.1(25/48)59.7(37/62)
fR10.523 (0.348, 0.698)0.2160.18278.6(11/14)39.6(19/48)48.4(30/62)
R20.518 (0.332, 0.704)0.2460.17371.4(10/14)45.8(22/48)51.6(32/62)
Table 3 Apparent diffusion coefficient and intravoxel incoherent motion derived parameters: Spearman correlation coefficients of the parameters with the histopathological grades
Spearman correlationADCDD*f
R1GradeCorrelation coefficient-0.619-0.628-0.2990.130
P-value< 0.001< 0.0010.0180.313
R2GradeCorrelation coefficient-0.622-0.633-0.3030.121
P-value< 0.001< 0.0010.0170.349