Rodrigues-Fleming GH, Fernandes GMM, Russo A, Biselli-Chicote PM, Netinho JG, Pavarino ÉC, Goloni-Bertollo EM. Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer. World J Gastroenterol 2018; 24(39): 4462-4471 [PMID: 30356976 DOI: 10.3748/wjg.v24.i39.4462]
Corresponding Author of This Article
Eny Maria Goloni-Bertollo, PhD, Adjunct Professor, Postdoc, Genetics and Molecular Biology Research Unit - UPGEM, Department of Molecular Biology, São José do Rio Preto Medical School (FAMERP), Av. Brigadeiro Faria Lima, - 5416 - Vila São Pedro, São José do Rio Preto, SP 15090-000, Brazil. eny.goloni@famerp.br
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 21, 2018; 24(39): 4462-4471 Published online Oct 21, 2018. doi: 10.3748/wjg.v24.i39.4462
Table 1 Sociodemographic characteristics, risk factors, and polymorphisms GSTT1, GSTM1, GSTP1 A313G in patients with colorectal cancer and controls n (%)
Table 3 Distribution of the clinical-histopathological parameters in relation to the polymorphisms in the genes GSTP1, GSTT1, and GSTM1 in patients with colorectal cancer n (%)
Table 4 Association between the double combined GSTT1/GSTM genotypes and triple combined GSTT1/GSTM/GSTP1, colorectal cancer, tumor progression, and primary site, adjusted for gender, age, smoking, and alcohol consumption
Table 5 Polymorphisms GSTT1, GSTM1, and GSTP1 in relation to overall survival of colorectal cancer patients
Polymorphisms
Survival (5 yr)
GSTT1
Positive
64
Negative
68
GSTM1
Positive
67
Negative
63
GSTP1 A313G
AA
61
AG
70
GG
63
Citation: Rodrigues-Fleming GH, Fernandes GMM, Russo A, Biselli-Chicote PM, Netinho JG, Pavarino ÉC, Goloni-Bertollo EM. Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer. World J Gastroenterol 2018; 24(39): 4462-4471