Basic Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Oct 7, 2018; 24(37): 4254-4262
Published online Oct 7, 2018. doi: 10.3748/wjg.v24.i37.4254
Table 1 Tumor formation rate and tumor load in each group
GroupnTumor formation rate (%)Tumor load (cm)P value (vs model group)
5-ASA2065.0 (13/20)0.43 ± 0.140.0269
VSL#32065.0 (13/20)0.25 ± 0.070.0009
5-ASA + VSL#31963.2 (12/19)0.46 ± 0.110.0261
Model19100.0 (19/19)0.97 ± 0.19-
Control1000-
Table 2 Level of tumor necrosis factor-α in colon tissue in each group
GroupnTNF-α (pg/mg tissue)P value (vs model group)
5-ASA814.66 ± 0.72< 0.05
VSL#3825.89 ± 5.25< 0.05
5-ASA + VSL#3821.33 ± 4.55< 0.05
Model868.38 ± 18.73-
Control810.49 ± 0.30< 0.01
Table 3 Level of interleukin-6 in colon tissue in each group
GroupnIL-6 (pg/mg tissue)P value (vs model group)
5-ASA828.19 ± 6.80< 0.0001
VSL#3899.71 ± 31.14< 0.0500
5-ASA+VSL#3881.43 ± 26.98< 0.0100
Model8254.20 ± 32.49-
Control825.47 ± 5.50< 0.0001
Table 4 Comparison of fecal microbiota (abundance)
GenusControl (%)Model (%)5-ASA (%)VSL#3 (%)5-ASA + VSL#3 (%)
Lactobacillus4.773.2612.654.069.864
Oscillibacter0.641.3010.5420.5230.794
Lachnoclostridium0.451.1910.4820.3931.08
Bacillus1.010.9824.00223.3430.66
Lactococcus2.302.298.5827.8631.59
Table 5 Comparison of mucosal microbiota (abundance)
GenusControl (%)Model (%)5-ASA (%)VSL#3 (%)5-ASA + VSL#3 (%)
Alloprevotella0.261.5711.160.951.22
Ruminococcaceae_UCG-0146.631.4911.641.501.15
Bifidobacterium3.450.2410.193.3421.903
Lachnoclostridium0.240.402.050.252.033