Review
Copyright ©The Author(s) 2018.
World J Gastroenterol. Sep 28, 2018; 24(36): 4104-4118
Published online Sep 28, 2018. doi: 10.3748/wjg.v24.i36.4104
Table 1 MicroRNA targets involved in alcoholic liver disease pathogenesis
miRNASource of samplemiRNA target
let-7[27]Animal modelsLin28, HMGA2
Human HSCs
miR-19b[28]Animal modelsTGFβRII, Col1α2, MeCP2
Human HSCs
miR-21[36,37]Animal modelsFASLG, DR5, Crebl2
miR-26a[35]Animal modelsDUSP4, DUSP5
miR-27a[44,52]Animal modelsSprouty2, CD206
HMC
Humans (plasma)
miR-34a[29,43]Animal modelsSIRT1, CASP2
Human HSCs
NHH
HiBECs
Humans (liver biopsy)
miR-103 and miR-107[53]Humans (liver biopsy)Caveolin-1
miR-122[32,124,125]Animal modelsP4HA1, HO-1, Cyclin G1, Bcl-w, HIF-1α
miR-155[38,39,97,126,127]Animal modelsTNFα, SHIP1, SOCS1, IRAKM, C/EBPβ
miR-181b-3p[40]Animal modelsImportin α1
miR-182[30]Animal modelsSLC1A1, Cofilin 1, CCL20, CXCL1, IL-8, Cyclin D1, IL-6
Humans (serum samples and liver biopsy)
miR-199[128]Animal modelsET-1, ET-BR
miR-200a[31]Animal modelsZEB-2
miR-212[46]Caco-2 cellsZO-1
Humans (colon biopsy)
miR-214[24,34]Animal modelsPOR, GSR, CYP2E1
HHCs
miR-217[41]Animal modelsSIRT-1
miR-223[45]Animal modelsp47phox, IL-6
Humans (serum)
miR-291b[42]Animal modelsTollip
HPBMs
miR-378[59]Animal modelsGli-3
miR-497[25]Animal modelsBtg2, Yy1
Table 2 Summary of microRNAs associated with non-alcoholic fatty liver disease
miRNASource of samplesChangeMain targets
miR-9[129]Human serum;UpregulatedOnecut2; SIRT1
Human hepatocyte cell line
miR-10b[130]Human hepatocyte cell lineDownregulatedPPARα
miR-15b[131,132]Animal modelsUpregulated
Human serum
miR-16[104]Human serumUpregulated
miR-17[74]Human liverDownregulated
miR-19[84]Human serumUpregulated
miR-21[86,87,99,133-136]Animal modelsUpregulatedPPARα; TGF-β
Human hepatocyte cell linePTEN
Human liver and serum
miR-21[85,89,137,138]Animal modelsDownregulatedHMGCR; FABP7
Human liver
Human hepatocyte cell line
miR-24[139]Animal modelsUpregulatedInsig1; SREBP
Human hepatocyte cell line
miR-26[140]Animal modelsDownregulatedIL-6, IL-7
miR-27a[141]Animal modelsDownregulated
miR-27b[102]Human serumUpregulated
miR-29a[142,143]Animal modelsDownregulatedHMGCR; LPL
miR-29c[85,89,90]Animal modelsDownregulatedDNMT3A; DNMT3B
miR-30b[83]Human liverDownregulatedITGAX; FABP4
Human hepatocyte cell line
miR-30c[144]Human serumUpregulated
miR-31[74,89]Human liverUpregulated
Animal models
miR-33a[73,76]Human liverUpregulatedABCA1; ABCA2
miR-33a[85]Human liverDownregulated
MiR-34a[71,81,82,85,87,89,90,92,104,105,145-148]Animal modelsUpregulatedSIRT1; HNF4α; PPARα
Human hepatocyte cell line
Human liver and serum
miR-99a[149]Human serumDownregulated
miR-101[150]Human hepatocyte cell lineUpregulatedABCA1
Human monocyte cell line
miR-103[53,89,151]Animal modelsUpregulatedCav1
Human liver and serum
miR-103a[152]Human liverUpregulated
Human hepatocyte cell line
miR-106b[152]Human liverUpregulated
miR-107[53,89]Animal modelsUpregulatedCav1
Human liver
miR-122[81,84,86,87,101-104,106,153]Animal modelsUpregulated
Human Serum
miR-122[71,82-85,89,90,99,106,141,154,155]Animal modelsDownregulatedACC-2; HAMP; FAS; HMGCR; SREBF-1c
Human liverSREPBF-2; HIF-1α; Vimentin; MAP3K3
miR-125b[84]Human serumUpregulated
miR-125b[156]Animal modelsDownregulatedFAS
miR-139-5p[83]Human liverDownregulatedTNFα
miR-144[76]Human LiverUpregulatedABCA1
miR-144[157]Animal modelsDownregulatedTLR-2
miR-146a[158]Animal modelsUpregulated
Human hepatocyte cell line
miR-146a[132]Animal modelsDownregulatedWnt1; Wnt5
Human hepatocyte cell line
Mir-146b[149,159]Animal modelsDownregulatedIRAK1
Human serumTRAF6
Human hepatocyte cell line
miR-146b[71,83,158]Animal modelsUpregulated
Human liver
Human hepatocyte cell line
miR-149[160]Animal modelsUpregulatedFGF-21
Human hepatocyte cell line
miR-150[74]Human liverUpregulated
miR-152[158]Animal modelsUpregulated
Human hepatocyte cell line
miR-155[90,97-99,161,162]Animal modelsUpregulatedSOCS1; C/EBP-Β; CES3; PDGF; SMAD3
Human hepatocyte cell line
miR-155[96]Animal modelsDownregulatedLXRα
Human liver and serum
miR-181a[82]Animal modelsUpregulated
miR-181d[149]Human serumDownregulated
miR-182[74]Human liverUpregulatedFOXO3
miR-183[74]Human liverUpregulated
miR-192[84,90]Animal modelsDownregulated
Human liver
miR-192-5p[82,84,86,102,106]Animal modelsUpregulated
Human liver and serum
miR-194[89]Animal modelsUpregulated
miR-197[149]Human serumDownregulated
miR-199[163]Animal modelsUpregulatedCav1; PPARα
Human hepatocyte cell line
Human liver
miR-200a/b/c[74,82,89,90,141,158,162,164]Animal modelsUpregulatedZEB1; CDH1; EZH2; IRP1
Human hepatocyte cell line
miR-203[90,132]Animal modelsDownregulated
miR-212[165]Animal modelsUpregulatedFGF-21
Human hepatocyte cell line
miR-214[71,166]Human liverUpregulated
Animal models
miR-216[167]Animal modelsDownregulated
miR-219a[74]Human liverDownregulated
miR-221[73]Human liverDownregulated
miR-221[89,90,99]Animal modelsUpregulated
miR-222[99]Animal modelsUpregulated
miR-223[86,164]Animals modelsUpregulatedIRP1
Human serum
miR-224[73,74]Human liverUpregulated
miR-291b[168]Animal modelsUpregulatedAMPKα1
miR-302a[167]Animals modelDownregulatedELOVL6
miR-331[144]Human serumUpregulated
miR-335[89]Animal modelsUpregulated
miR-375[84]Human serumUpregulated
miR-378i[74]Human liverDownregulated
miR-421[169]Animal modelsUpregulatedSIRT-3
miR-422a[83]Human liverDownregulated
miR-429[141]Animal modelsUpregulated
miR-451[87]Human SerumUpregulated
miR-451[89,141,170]Animal modelsDownregulatedAMPK/AKT
Human liver
miR-467b[171]Animal modelsDownregulatedLPL
miR-576[152]Human liverDownregulatedRAC1
Human hepatocyte cell line
miR-590[74]Human liverDownregulated
miR-892a[152]Human liverUpregulated
Human hepatocyte cell line
miR-1290[102]Human serumUpregulated