Retrospective Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Jul 14, 2018; 24(26): 2886-2892
Published online Jul 14, 2018. doi: 10.3748/wjg.v24.i26.2886
Table 1 Demographic and tumor characteristics for patients with lymph node-negative gallbladder carcinoma n (%)
CharacteristicsEntire cohortn = 893 (100%)Stage I1n = 228 (25.5%)Stage II1n = 444 (49.7%)Stage IIIA1n = 221 (24.7%)P2Value
Age, yr
Median (range)67 (21-96)67 (21-92)67 (25-96)67 (35-93)0.575
Sex
Male272 (30.5)63 (27.6)139 (31.3)70 (31.7)
Female621 (69.5)165 (72.4)305 (68.7)151 (68.3)0.559
Race
White675 (75.6)162 (71.1)34.1 (76.8)172 (77.8)
Black106 (11.9)33 (14.5)50 (11.3)23 (10.4)
Others112 (12.5)33 (14.5)53 (11.9)26 (11.8)0.261
Grade1
Well187 (20.9)67 (29.4)102 (23.0)18 (8.1)
Moderate414 (46.4)101 (44.3)215 (48.4)98 (44.3)
Poor210 (23.5)26 (11.4)96 (21.6)88 (39.8)
Undifferentiated11 (1.2)1 (0.4)5 (1.1)5 (2.3)
Unknown71 (8.0)33 (14.5)26 (5.9)12 (5.4)< 0.001
Radiation
Yes151 (16.9)8 (3.5)75 (16.9)68 (30.8)
No742 (83.1)220 (96.5)369 (83.1)153 (69.2)< 0.001
Vital status
Alive547 (61.3)151 (66.2)308 (69.4)88 (39.8)
Dead346 (38.7)77 (33.8)136 (30.6)133 (60.2)< 0.001
Number of LN
Median (range)2 (1-80)1 (1-80)2 (1-40)2 (1-24)0.590
Table 2 Survival by lymph node group and stage
Number of LNEntire cohort n = 893 (100%)Stage I1n = 228 (25.5%)Stage II1n = 444 (49.7%)Stage IIIA1n = 221 (24.7%)
1 LN
Patients (n)39812118988
Median OS, mo18242010
3-yr SR (95%CI)0.503 (0.474-0.532)0.603 (0.553-0.653)0.608 (0.566-0.650)0.271 (0.217-0.325)
5-yr SR (95%CI)0.393 (0.361-0.425)0.473 (0.418-0.528)0.445 (0.394-0.496)0.177 (0.128-0.226)
2 LNs
Patients (n)129356826
Median OS, mo28432715
3-yr SR (95%CI)0.711 (0.665-0.757)0.808 (0.737-0.879)0.775 (0.713-0.837)0.425 (0.317-0.533)
5-yr SR (95%CI)0.579 (0.524-0.634)0.725 (0.640-0.810)0.586 (0.504-0.668)0.340 (0.225-0.455)
3 LNs
Patients (n)85203332
Median OS, mo21302711
3-yr SR (95%CI)0.587 (0.525-0.649)0.722 (0.603-0.841)0.697 (0.606-0.788)0.379 (0.277-0.481)
5-yr SR (95%CI)0.466 (0.396-0.536)0.602 (0.454-0.750)0.639 (0.539-0.739)0.203 (0.109-0.297)
4 LNs
Patients (n)5583116
Median OS, mo22222710
3-yr SR (95%CI)0.638 (0.560-0.716)0.833 (0.681-0.985)0.760 (0.671-0.849)0.295 (0.154-0.446)
5-yr SR (95%CI)0.533 (0.438-0.628)0.833 (0.681-0.985)0.652 (0.526-0.778)0.148 (0.022-0.274)
5 LNs
Patients (n)43102112
Median OS, mo24382418
3-yr SR (95%CI)0.750 (0.671-0.829)0.857 (0.725-0.989)NA0.292 (0.133-0.451)
5-yr SR (95%CI)0.652 (0.557-0.747)0.714 (0.543-0.885)0.857 (0.725-0.989)0.146 (0.016-0.276)
≥ 6 LNs
Patients (n)1833410247
Median OS, mo26262621
3-yr SR (95%CI)0.696 (0.655-0.737)0.817 (0.731-0.903)0.753 (0.701-0.805)0.498 (0.412-0.584)
5-yr SR (95%CI)0.594 (0.547-0.641)0.817 (0.731-0.903)0.671 (0.610-0.732)0.306 (0.221-0.391)
Table 3 Multivariate analyses for overall survival in patients with lymph node-negative gallbladder carcinoma
VariableEntire cohortn = 893 (100%)
Stage I1n = 228 (25.5%)
Stage II1n = 444 (49.7%)
Stage IIIA1n = 221 (24.7%)
HR (95%CI)aPHR (95%CI)bPHR (95%CI)cPHR (95%CI)dP
Age, yr1.001 (1.000-1.002)0.5041.001 (1.000-1.002)0.9341.001 (1.000-1.002)0.4491.001 (1.000-1.002)0.057
Sex
Male1111
Female0.684 (0.532-0.879)0.0030.317 (0.156-0.645)0.0020.553 (0.346-0.881)0.0130.494 (0.299-0.818)0.006
Race
White1111
Black1.475 (1.008-2.160)0.0464.593 (1.625-12.981)0.0041.645 (0.775-3.490)0.1952.245 (0.904-5.575)0.082
Others0.821 (0.551-1.224)0.3340.262 (1.975)0.7190.509 (0.245-1.056)0.0701.362 (0.609-3.047)0.452
Grade1
Well1111
Moderate0.840 (0.609-1.157)0.2860.418 (0.194-0.902)0.0261.568 (0.905-2.715)0.1090.297 (0.125-0.704)0.006
Poor1.291 (0.908-1.835)0.1551.339 (0.449-3.994)0.6012.412 (1.306-4.453)0.0050.629 (0.259-1.531)0.307
Undifferentiated2.101 (0.891-4.954)0.090//4.059 (1.033-15.951)0.0451.434 (0.323-6.373)0.636
Unknown0.856 (0.503-1.455)0.5650.384 (0.134-1.106)0.0762.376 (0.857-6.583)0.0960.260 (0.068-1.003)0.050
Radiation
No1111
Yes0.727 (0.515-1.027)0.0711.055 (0.302-3.688)0.9330.781 (0.430-1.419)0.4170.390 (0.215-0.708)0.002
No. of LNs examined1.001 (1.000-1.002)0.1621.001 (1.000-1.002)0.9101.001 (1.000-1.002)0.3821.001 (1.000-1.002)0.167
Stage1
 I1//////
II1.089 (0.793-1.497)0.598//////
IIIA3.730 (2.635-5.280)0.000//////