Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers

Table 1 Intra-individual comparison of induced tumor necrosis (%) between primary hepatocellular carcinomas and intrahepatically implanted R1 rhabdomyosarcomas in combretastatin-A4-phosphate-treated group

Rat	Primary HCC					Implanted hepatic R1
	Tumor code	CA4P-induced necrosis, %	Tumor diameter in mm	Tumor vascularity1	Tumor differentiation2	Tumor code	CA4P-induced necrosis, %	Tumor diameter in mm	Tumor vascularity1
1	HCC_1	21.8	9.7	++	II	R1_1	72.3	12.1	++
	HCC_2	16.4	6.5	++	III-IV
	HCC_3	0	10.9	++	III
2	HCC_4	43.1	6.4	+	III	R1_2	84.5	12.6	++
	HCC_5	23.3	8.5	++	III
3	HCC_6	92.3	8.1	+	I-II	R1_3	99.2	10	++
	HCC_7	96.5	6.2	+	II
	HCC_8	19.8	10	+	I
	HCC_9	98.9	10	+	II
4	HCC_10	99.2	14.3	+	I-II	R1_4	96.8	9.8	++
5	HCC_11	27.6	18.3	+	III	R1_5	99.4	8.3	++
	HCC_12	4.9	7.8	++	II-III
	HCC_13	62.7	13	+	I-II
6	HCC_14	47.6	14.2	+, +++3	I, III4	R1_6	97.7	9	++
	HCC_15	46.4	14.2	+, +++3	I, III4
7	HCC_16	76.1	12.5	+	II-III	R1_7	98.3	6.2	++
	HCC_17	552.6	11.9	+	III
	HCC_18	33.4	10.4	+	III
	HCC_19	91.2	9	+	I-II
Mean ± SD		50.2 ± 1.8	10.6 ± 0.2	/	/		92.6 ± 1.5	9.7 ± 0.3	/

¹A vascular scoring system for rat liver tumor: vascular density similar to that of liver parenchyma (+), denser vasculature without vascular lakes (++), denser vasculature with small-sized vascular lakes (+++), and full of large vascular lakes (++++);

²A 4-scale grading system for HCC differentiation in rats: Well (I), moderately (II), poorly (III) and un-(IV) differentiated HCC lesions;

³Tumor vascularity was graded as + in the necrotic tumor, and +++ in the residual viable part;

⁴HCC differentiation was scored by I in the necrotic tumor, and III in the residual viable part. HCC: Hepatocellular carcinoma; SD: Standard deviation.