Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

Table 1 Mouse models of nonalcoholic steatohepatitis-associated hepatocellular carcinoma

List	Backgrounds	Inducer of NASH/HCC	Carcinogenic duration	HCC occurrence (%)	Ref.
PTEN null mice	Genetic	Spontaneous	40 wk	66 (74-78 wk)	[12,17,18,21,22]
MC4R KO mice	Genetic	HFC diet	1 yr	100	[13,29,31]
STAM mice	DM/HL	Streptozotocin, HFC diet	20 wk	100	[14,32-36]
ALR KO mice	Genetic	Spontaneous	1 yr	60	[15]

HFC: High fat/calorie; DM: Diabetes; HL: Hyperlipidemia; HCC: Hepatocellular carcinoma; NASH: Nonalcoholic steatohepatitis.