Olfactomedin-4 in digestive diseases: A mini-review

Table 1 Effects of olfactomedin-4 in digestive diseases

Disease	Expression	Function	Regulation
H. pylori infection	Up-regulated in the H. pylori–infected gastric mucosa	Negative regulator of H. pylori-specific immune responses	NF-κB, NOD-1/2, MyD88
Inflammatory bowel disease	Up-regulated in the intestinal epithelium in Crohn’s disease and ulcerative colitis	Mucosal defense, anti-inflammatory effects	Notch, TNF-α
Gastrointestinal malignancies	Up-regulated in well/moderately differentiated, early-stage gastrointestinal malignancies without lymphatic metastasis	Biomarker, candidate therapeutic target	NF-κB, TNF-α, miR-486, Wnt/β-catenin

H. pylori: Helicobacter pylori.