Serum interleukin-34 level can be an indicator of liver fibrosis in patients with chronic hepatitis B virus infection

Table 1 Levels of interleukin-34 in patients with different stages of liver fibrosis

Stage	n	Median	95%CI
S0 patients and healthy subjects	34	10.05	9.28-11.27
S1-S2 patients	93	11.53	10.38-13.92
S3-S4 patients	67	19.84	17.34-20.63

CI: Confidence interval.

Table 2 Area under the curves for different fibrosis scores for the various stages of fibrosis

	AUC (95%CI)
	S0 vs S1-S4	S3-S4 vs S0-S2	S4 vs S0-S3
IL-34	0.753 (0.659-0.848)	0.809 (0.743-0.875)	0.815 (0.747-0.883)
APRI	0.714 (0.580-0.847)	0.783 (0.715-0.850)	0.797 (0.710-0.884)
FIB-4	0.577 (0.427-0.727)	0.651 (0.564-0.738)	0.651 (0.529-0.773)
Forns	0.529 (0.405-0.653)	0.762 (0.685-0.839)	0.788 (0.689-0.886)
FCI	0.580 (0.422-0.738)	0.793 (0.723-0.863)	0.822 (0.739-0.906)
Liver stiffness	0.684 (0.565-0.803)	0.844 (0.784-0.903)	0.815 (0.728-0.902)

APRI: Aspartate aminotransferase to platelet ratio index; AUC: Area under the curves; CI: Confidence interval; FCI: Fibrosis-cirrhosis index; FIB-4: Fibrosis-4; IL: Interleukin.