Esophagogastric junction distensibility assessed using the functional lumen imaging probe

Table 1 Summary of all eligible studies

Ref.	Quality Score	n (pre-intervention)	n (post-intervention)	Bag length (cm)	Bag volume(s) (mL)
Healthy
Fukazawa et al[4], 2014	7	9	N/A	8	20, 40, 50
Lin et al[18], 2013	6	10	N/A	16	30, 40, 50, 60
Rieder et al[8], 2013	7	4	N/A	8	30, 40
Rohof et al[19], 2012	7	15	N/A	14	50
Nathanson et al[7], 2012	7	50	N/A	8	30
Kwiatek et al[5], 2011	8	15	N/A	10	20, 30, 40
Kwiatek et al[6], 2010	6	20	N/A	7	10, 20, 30, 40
Kwiatek et al[17], 2010	6	10	N/A	12	30, 40, 50, 60
Beaumont et al[16], 2009	5	8	N/A	10	60
Achalasia
Teitelbaum et al[13], 2014	8	56	LHM (20), POEM (36)	8	40
Familiari et al[9], 2014	7	23	POEM (21)	8	30
Teitelbaum et al[12], 2014	8	31	LHM (12), POEM (19)	8	30, 40
Teitelbaum et al[11], 2013	8	25	LHM (11), POEM (14)	8	30, 40, 50
Verlaan et al[20], 2013	8	10	POEM (8)	14	20, 30, 40, 50
Pandolfino et al[10], 2013	8	23	treated (31)	10	20, 30, 40
Rieder et al[8], 2013	7	4	POEM (4)	8	30, 40
Rohof et al[19], 2012	7	30	Treated (30)	14	50
GERD
Rinsma et al[15], 2014	7	15	TIF (15)	8	30
Ilczyszyn et al[14], 2014	8	17	Nissen (17)	8	30, 40
Kwiatek et al[6], 2010	6	20	N/A	7	10, 20, 30, 40
Kwiatek et al[17], 2010	6	10	Fundoplicstoin (10)	12	30, 40, 50, 60
Beaumont et al[16], 2009	5	7	RFA (7)	10	60

Table 2 Healthy subjects

Healthy	Distensibility1 (mm2/mmHg)	CSA1 (mm2)
20 mL bag volume
Kwiatek et al[17], 2010	Median 2 (5%-95% 1-9)	Median 38 (5%-95% 13-94)
Fukazawa et al[4], 2014	2.9 ± 0.6	25.2 ± 2.5
Kwiatek et al[5], 2011	Median 0.9 (5%-95% 0.3-1.4)	Median 15 (5%-95% 9-23)
30 mL bag volume
Kwiatek et al[17], 2010	Median 4 (5%-95% 1-14)	Median 94 (5%-95% 27-225)
Reider et al[8], 2013	Median 2.5 (range 2.0-6.3)	Median 64 (range 44-91)
Nathanson et al[7], 2012	Median 1.4	Median 31
Kwiatek et al[5], 2011	Median 0.8 (5%-95% 0.4-2.8)	Median 22 (5%-95% 9-62)
Kwiatek et al[17], 2010	N/A	Median 502 (5%-95% 50-68)
Lin et al[18], 2013	Median 3.2 (5%-95% 1-11.6)	N/A
40 mL bag volume
Kwiatek et al[17], 2010	N/A	Median 264 (5-95% 99-496)
Fukazawa et al[4], 2014	7.1 ± 0.9	163 ± 5.9
Rieder et al[8], 2013	Median 2.7 (range 2.4-8.3)	Median 122 (range 73-171)
Kwiatek et al[6], 2010	N/A	Median 502 (5%-95% 50-50)
Lin et al[18], 2013	Median 5.7 (5%-95% 1.4-15.8)	N/A
50 mL bag volume
Fukazawa et al[4], 2014	8.2 ± 0.8	259.6 ± 12
Kwiatek et al[17], 2010	N/A	Median 502 (5%-95% 50-52)
Rohof et al[19], 2012	6.3 ± 0.7	N/A
Lin et al[18], 2013	Median 5.9 (5-95% 1.6-9.3)	N/A
60 mL bag volume
Beaumont et al[16], 2009	3.7 ± 0.93	N/A
Kwiatek et al[17], 2010	N/A	Median 93 (5%-95% 50-182)
Lin et al[18], 2013	Median 6.3 (5%-95% 2.1-9.5)	N/A

¹Values given in mean unless specified otherwise;

²The minimal detectable CSA was 50 mm²;

³Values indicate compliance (cm²/cmH₂O).

Table 3 Gastroesophageal reflux disease subjects

GERD	Intervention (n)	Intra-Op(Y/N)	Pre-treatment Distensibility1(mm2/mmHg)	Post-treatment Distensibility1(mm2/mmHg)	Pre-TreatmentCSA1 (mm2)	Post-treatmentCSA1 (mm2)
20 mL bag volume
Kwiatek et al[5], 2010	N/A	N	Median 7 (5%-95% 1-32)	N/A	Median 36 (5%-95% 13-201)	N/A
30 mL bag volume
Kwiatek et al[6], 2010	N/A	N	Median 8 (5%-95% 1-46)	N/A	Median 116 (5%-95% 33-344)	N/A
Rinsma et al[15], 2014	TIF (15)	Y	2.4 ± 0.3	1.6 ± 0.2	40.6 ± 5.4	33.6 ± 4.1
Ilczyszyn et al[14], 2014	Nissen (17)	Y	Median 4.23 (IQR 1.60-6.58)	Median 0.972 (IQR 0.715-1.72)	Median 75.1
Kwiatek et al[17], 2010	Fundoplication (10)	N	N/A	N/A	N/A	Median 51 (5%-95% 50-60)
40 mL bag volume
Kwiatek et al[17], 2010	N/A	N	N/A	N/A	Median 180 (5%-95% 86-409)	N/A
Ilczyszyn et al[14], 2014	Nissen (17)	Y	Median 3.75 (IQR 2.43-7.21)	Median 1.36 (IQR 0.537-2.85)	Median 124.2	N/A
Kwiatek et al[17], 2010	Fundoplication (10)	N	N/A	N/A	N/A	Median 51 (5%-95% 50-56)
50 mL bag volume
Kwiatek et al[17], 2010	Fundoplication (10)	N	N/A	N/A	N/A	Median 61 (5%-95% 52-88)
60 mL bag volume
Beaumont et al[16], 2009	Radiofrequency ablation	N	6.5 ± 0.92	7.3 ± 1.32	N/A	N/A
Kwiatek et al[17], 2010	Fundoplication (10)	N	N/A	N/A	N/A	Median 159 (5%-95% 68-245)

¹Values given in mean unless specified otherwise;

²Values indicate compliance (cm²/cmH₂O). GERD: Gastroesophageal reflux disease.

Table 4 Achalasia subjects

Achalasia	Intervention (n)	Pre-treatment Distensibility1(mm2/mmHg)	Post-treatment Distensibility1(mm2/mmHg)	Pre-treatment CSA1(mm2)	Post-treatment CSA1(mm2)
20 mL bag volume
Pandolfino et al[10], 2013	Untreated (23)	Median 1.1 (5%-95% 0.9-1.6)	Median 1.8 (5%-95% 1.2-2.2)	N/A	N/A
	Treated2 (17)
Verlaan et al[20], 2013	10	Median 1.4 (IQR 1.1-2.4)	POEM: Median 3.0 (IQR 1.4-9.4)	N/A	N/A
30 mL bag volume
Familiari et al[9], 2014	POEM (21)	N/A	N/A	32.9 ± 23.1	102.38 ± 28.2
Teitelbaum et al[11], 2014	LHM (12)	LHM: 2.2 ± 1.7	LHM: 6.9 ± 3.3	N/A	N/A
	POEM (19)	POEM: 1.8 ± 1.4	POEM: 9.3 ± 4.1
Teitelbaum et al[12], 20133	LHM (11)	LHM: 1.7 ± 1.5	LHM: 6.7 ± 4.4	N/A	N/A
	POEM (14)	POEM: 1.8 ± 1.1	POEM: 8.2 ± 3.0
Rieder et al[8], 2013	POEM (4)	Median 0.8 (range 0.7-1.0)	Median 3.1 (range 1.7-3.4)	Median 22 (range 20-32)	Median 71.5 (range 30-106)
Pandolfino et al[10], 2013	Untreated (23)	Median 1.0 (5%-95% 0.8-1.2)	Median 2.5 (5%-95% 1.3-3.4)	N/A	N/A
	Treated2 (17)
Verlaan et al[20], 2013	10	Median 1.0 (IQR 0.8-1.5)	POEM: Median 2.9 (IQR 1.3-19.6)	N/A	N/A
40 mL bag volume
Rieder et al[8], 2013	POEM (4)	Median 1.0 (range 0.5-1.4)	Median 2.4 (range 1.1-3.0)	Median 41.5 (range 20-49)	Median 86 (range 41-137)
Teitelbaum et al[11], 2014	LHM (12)	LHM: 1.6 ± 1.0	LHM: 6.3 ± 3.4	N/A	N/A
	POEM (19)	POEM: 1.3 ± 1.0	POEM: 9.2 ± 3.9
Teitelbaum et al[12], 2014	LHM (20)	LHM: 1.5 ± 1.2	LHM 6.6 ± 3.1	N/A	N/A
	POEM (36)	POEM: 1.3 ± 1.4	POEM 8.3 ± 3.4
Teitelbaum et al[13], 20133	LHM (11)	LHM: 1.4 ± 1.3	LHM: 7.6 ± 4.4	LHM 33.5	LHM 163.6
	POEM (14)	POEM: 1.4 ± 1.9	POEM: 7.9 ± 2.7	POEM 38.8	POEM 163.3
Pandolfino et al[10], 2013	Untreated (23)	Median 0.7 (5%-95% 0.5-1.1)	Median 3.4 (5%-95% 2.2-4.9)	N/A	N/A
	Treated (17)
Verlaan et al[20], 2013	10	Median 1.1 (IQR 0.55-2.0)	POEM: Median 4.0 (IQR 2.9-12.7)	N/A	N/A
50 mL bag volume
Teitelbaum et al[11], 20133	LHM (11)	LHM: 1.1 ± 0.9	LHM: 5.7 ± 3.1	N/A	N/A
	POEM (14)	POEM: 1.4 ± 2.1	POEM: 6 ± 1.5
Rohof et al[19], 2012	7 Treated (6 PD, 1 LHM)	0.7 ± 0.9	4.4 ± 0.5	N/A	N/A
Verlaan et al[20], 2013	10	Median 1.0 (IQR 0.4-2.3)	POEM: Median 6.7 (IQR 3.8-16.6)	N/A	N/A

¹Values given in mean unless specified otherwise;

²Treated included patients that underwent pneumatic dilation, Heller myotomy with partial fundoplication, and POEM with good response;

³Subjects were included in the more recent Teitelbaum study (2014). CSA: Cross-sectional area; LHM: Laparoscopic Heller Myotomy; POEM: Peroral endoscopic myotomy; PD: Pneumatic dilation.