Retrospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Dec 28, 2017; 23(48): 8570-8581
Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8570
Table 1 Clinical information for 19 allergic colitis infants
IDGenderAge (mo)Symptom(s)Duration of disease (mo)Treatment(s) before FMTDonor sourceFMT timesSymptom remission after first FMT (d)Stool frequency before and after FMT (times/d)Follow-up (mo)Availability of gut microbiota data
AC1Female7Diarrhea, hematochezia sometimes; anemia; hypohepatia> 3Applying amino acid formula and probiotics (C. butyricum)Mother213-4, 119Yes
AC2Male10Hematochezia> 0.5Applying amino acid formula and probiotics (Bifidobacteria)Healthy infants aged 10 mo old212-3, 118Yes
AC3Female11Hematochezia> 3Applying amino acid formula and probiotics (S. boulardii)Healthy infants aged 8 mo old315-6, 219Yes
AC4Male9Hematochezia> 3Applying amino acid formula and probiotics (S. boulardii)Mother's cousin sister316-7, 1-218Yes
AC5Male5Diarrhea and hematochezia sometimes> 3Applying amino acid formulaHealthy infants aged 8 mo old313-4, 219Yes
AC6Male5Hematochezia> 3Applying amino acid formula and probiotics (C. butyricum)Mother125-6, 118Yes
AC7Male4Hematochezia and cough sometimes> 2Applying amino acid formula and nebulizationMother224-7, 115Yes
AC8Female3Diarrhea and mucoid feces sometimes> 2Applying amino acid formulaMother213-4, 1-219Yes
AC9Male11Interval hematochezia> 6Appling amino acid formula and probiotics (S. boulardii)Mother213-4, 223Yes
AC10Female3Hematochezia> 1.5Applying amino acid formulaHealthy infants aged 10 mo old425-6, 121Yes
AC11Male7Diarrhea> 2Applying amino acid formula, probiotics (Bifidobacteria), Smecta and Oral Rehydration Salts (ORS)Healthy infants aged 10 mo old515-6, 123No
AC12Female10Diarrhea and hematochezia sometimes> 1Applying amino acid formula and probiotics (Bifidobacteria)Mother315-6, 1-222No
AC13Male5Hematochezia and diahhrea sometimes> 3Applying amino acid formulaMother113-4, 115No
AC14Female5Hematochezia and then peptone shaped feces> 1Applying amino acid formula and probiotics ()Mother117-8, 215No
AC15Male7Diarrhea> 2Applying amino acid formula, ORS, and probiotics (C. butyricum)Mother515-6, 121No
AC16Female5Interval hematochezia> 2Appling amino acid formulaHealthy infants aged 8 mo old214-5, 121No
AC17Male7Diarrhea and hematochezia sometimes> 3Applying amino acid formula, probiotics (Bifidobacteria and C. butyricum)Healthy infants aged 11 mo old123-4, 1-20.5No
AC18Female8Diarrhea and cough sometimes> 4Applying amino acid formula and nebulizationHealthy infants aged 8 mo old213-4, 217No
AC19Male5Interval diarrhea> 4Applying amino acid formulaMother413-4, 10.3No
Table 2 Laboratory testing on donors
Blood testing
Blood transfusion examinations: Quantifications of hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B E antigen, hepatitis B E antibody, hepatitis B core IgM antibody, hepatitis C antibody, human immunodeficiency virus antibody, and treponema pallidum antibody.
TORCH examinations: Detections on toxoplasmosis IgG, toxoplasmosis IgM, rubella virus IgG, rubella virus IgM, cytomegalovirus IgG, cytomegalovirus IgM, herpes simplex virus 1/2 IgG, and herpes simplex virus 1/2 IgM.
Detection on parvovirus B19.
Epstein-Barr virus examinations: Detections on Epstein-Barr virus capsid antigen IgA, Epstein-Barr virus capsid antigen IgG, Epstein-Barr virus capsid antigen IgM, Epstein-Barr virus early antigen IgG, and Epstein-Barr virus nuclear antigen IgG.
Blood type examination.
Lymphocyte subpopulation examination.
Food allergen examination (sIgE).
Hepatic and renal function examinations: Glutamic-pyruvic transaminase, glutamic oxalacetic transaminase, total protein, albumin, globulin, prealbumin, total bilirubin, direct bilirubin, indirect bilirubin, alkaline phosphatase, gamma glutamyltranspeptidase, total cholesterol , triglycerides, high-density lipoprotein, low density lipoprotein, apolipoprotein A1, apolipoprotein B, lactic dehydrogenase, calcium, corrected calcium, phosphorus, magnesium, urea, creatinine, trioxypurine, bicarbonate radical, total bile acid, 5-nucleotidase, α-L-fucosidase, cholinesterase, cystatin C, and lipase andamylopsin.
Mycobacterium tuberculosis antibody examination (or the enzyme-linked immuno-spot assay test for tuberculosis).
Immune system examinations: Quantifications of immune globulin A, immune globulin G, immune globulin M, alexin C3, and alexin C4.
Detection on hepatitis A-IgM.
Qualifications of C-reaction protein and erythrocyte sedimentation rate.
Stool testing
Fecal routine examinations: Detections on fecal color, character, red blood cells, white blood cells, occult blood, parasite eggs, protozoon, fat ball, rotavirus antigen, and fungus.
Bacterial culture tests: Detections on Vibrio cholera, Salmonella, Shigella, Aeromonas, Plesiomonas, and pathogenic Escherichia coli.
Other testing
Chest X-ray.
Urea[C13] Capsule Breath Test.
Abdominal ultrasound scan.
Electrocardiographic examination.
Table 3 Laboratory testing of the patients before fecal microbiota transplantation
Blood testing
Hepatic and renal function examinations: Glutamic-pyruvic transaminas, glutamic oxalacetic transaminase, total protein, albumin, globulin, prealbumin, total bilirubin, direct bilirubin, indirect bilirubin, alkaline phosphatase, gamma glutamyltranspeptidase, total cholesterol, triglycerides, high-density lipoprotein, low density lipoprotein, apolipoprotein A1, apolipoprotein B, lactic dehydrogenase, calcium, corrected calcium, phosphorus, magnesium, urea, creatinine, trioxypurine, bicarbonate radical, total bile acid, 5-nucleotidase, α-L-ducosidase, cholinesterase, cystatin C, lipase, and amylopsin.
Food allergen examination (sIgE).
Lymphocyte subpopulation examination.
Detection on hepatitis A-IgM.
Blood transfusion examinations: Quantifications of hepatitis B surface antigen, hepatitis B surface antibody, hepatitis B E antigen, hepatitis B E antibody, hepatitis B core IgM antibody, hepatitis C antibody, human immunodeficiency virus antibody, and treponema pallidum antibody.
TORCH examinations: Detections on toxoplasmosis IgG, toxoplasmosis IgM, rubella virus IgG, rubella virus IgM, cytomegalovirus IgG, cytomegalovirus IgM, herpes simplex virus 1/2 IgG, and herpes simplex virus 1/2 IgM.
Detection on parvovirus B19.
Blood coagulation examinations: Detections on prothrombin time, prothrombin activity, international normalized ratio, fibrinogen, activated partial thromboplastin time, thrombin time, and D-dimer.
Blood type examination.
Mycobacterium tuberculosis antibody examination (or the enzyme-linked immuno-spot assay test for tuberculosis).
Stool testing
Fecal routine examinations: Detections on fecal color, character, red blood cells, white blood cells, occult blood, parasite eggs, protozoon, fat ball, rotavirus antigen, and fungus.
Bacterial culture tests: Detections on Vibrio cholera, Salmonella, Shigella, Aeromonas, Plesiomonas, and pathogenic Escherichia coli.
Other testing
Enteroscopic examination.
Abdominal ultrasound scan (intestinal adhesion).
Electrocardiographic examination.