Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding

Table 1 The demographic and clinical characteristics of subjects

Parameters	AIH	HC
No	20	35
Age (yr)	47.2 ± 11.8	46.9 ± 9.9
Patient age at diagnosis(yr)	44.5 ± 11.8	-
Gender: female/male	16/4	27/8
IAIHG score	17.15 ± 2.23	-
ALT (< 40 IU/L)	301.7 ± 284.7b	21.9± 9.5
AST (< 40 IU/L)	306 ± 224.4b	21.8 ± 4.9
ALP (< 114 IU/L)	190 ± 130.4b	69 ± 21
Total Bilirubin (6-21 μmol/L)	112.5 ± 116.1b	13.6 ± 3.7
Albumin (38-51 g/L)	38.2 ± 6.9a	45.2 ± 8.4
IgG (7-16 g/L)	24.1 ± 11.8b	8.4 ± 2.8
Ant-ANA (+) (≥ 1:100)	15 (75)	-
Ant-SMA (+) (≥ 1:100)	3 (15)	-
Ant-ANA (+) + Ant-SMA(+)	2 (10)	-
Ant-LKM-1 (+) (≥ 1:40)	0	-
Cirrhosis at presentation	7 (35)	-

Data are expressed as n (%) or mean ± SD.

^aP < 0.05,

^bP < 0.01 vs HC. AIH: Autoimmune hepatitis; IAIHG: International autoimmune hepatitis group; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphate; IgG: Immunoglobulin G; Ant-ANA: anti-nuclear antibody; ant-SMA: Anti-smooth muscle antibody; HC: Healthy control; AIH: Autoimmune Hepatitis; –: Not available.