Retrospective Cohort Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Dec 7, 2017; 23(45): 8017-8026
Published online Dec 7, 2017. doi: 10.3748/wjg.v23.i45.8017
Table 1 Characteristics of the pediatric patients receiving liver transplantation (n = 26) according to the presence or absence of HLA-DR NIMA-MC n (%)
Factors1NIMA-MC (+)NIMA-MC (-)P value
(n = 6)(n = 20)
Age at the time of transplantation in years (range)6.1 (1-14)6.7 (0-16)0.57
Age at the time of transplantation (less than 12 mo)3 (50.0)7 (35.0)0.64
Sex, male: female4 (66.7): 2 (33.3)6 (30.0): 14 (70.0)0.16
Recipient weight, kg (range)28.9 (10.8-54.5)27.8 (8.1-56.3)0.92
Original liver disease0.65
Biliary atresia4 (66.7)9 (45.0)
Others2 (33.3)11 (55.0)
ABO identical to that of mother3 (50.0)13 (65.0)> 0.99
Table 2 Biopsy-proven cellular rejection rate in pediatric patients receiving liver transplantation with maternal graft (n = 23) according to the presence or absence of pretransplantation HLA-DR NIMA-MC and HLA-DR match status n (%)
NIMA-MC and HLA-DR match statusBiopsy-proven cellular rejectionP valuea
NIMA-MC (-) (n = 10)5 (50.0)
NIMA-MC (+) (n = 3)0 (0)0.23
NIMA-MC (+) or HLA-DR 0 mismatch with mother (n = 11)2 (18.2)0.18
NIMA-MC (+) or HLA-DR identity with mother (n = 7)0 (0)0.04
Total transplantation with maternal graft (n = 23)8 (34.8)
Table 3 Characteristics of pediatric patients receiving liver transplantation with maternal graft (n = 17) according to the presence or absence of pretransplantation HLA-DR NIMA-MC and HLA-DR match status n (%)
Factors1NIMA-MC (+) or HLA-DR identity with motherNIMA-MC (-)P value
(n = 7)(n = 10)
Age at the time of transplantation in years, median (range)5.6 (0.8-10)7.3 (0.8-16)0.42
Age at the time of transplantation (less than 12 mo)3 (42.9)4 (40.0)> 0.99
Sex, male: female3 (42.9): 4 (57.1)4 (40.0): 6 (60.0)> 0.99
Recipient weight, kg, median (range)27.4 (6.2-54.5)26.0 (9.6-56.3)> 0.99
Original liver disease0.64
Biliary atresia4 (57.1)4 (40.0)
Others3 (42.9)6 (60.0)
Crossmatch positivity0 (0)1 (10.0)> 0.99
ABO identical to that of mother7 (100)7 (70.0)0.23
PELD score, median (range)11.2 (-7.7-39)2.3 (-10.0-14.1)0.27
The year of LT (before 2007)2 (28.6)3 (30.0)> 0.99
Donor age in years, median (range)34 (26-39)38 (33-43)0.16
Sex match, yes: no4:36:40.65
Operation time, median, min, median (range)443 (300-595)492 (285-710)0.46
Graft vs recipient weight ratio, %, median (range)2.68 (1.62-3.23)2.15 (1.23-2.96)0.40
Follow-up duration, mo, median (range)84 (63-176)66 (30-114)0.32
Graft failure0 (0)0 (0)> 0.99
Biopsy-proven cellular rejection0 (0)5 (50)0.04