Clinical outcomes of transcatheter selective superior mesenteric artery urokinase infusion therapy vs transjugular intrahepatic portosystemic shunt in patients with cirrhosis and acute portal vein thrombosis

Table 1 Baseline characteristics of the study population

Characteristic	SMA group (n = 20)	TIPS group (n = 20)	P value
Age (yr)1	48.4 ± 13.2	50.1 ± 8.6	0.632
Male sex	14	15	1.0003
Etiology			0.1563
HBV	14	17
HCV	0	1
Alcohol	5	1
Autoimmune	0	1
Cryptogenic	1	0
Child-Pugh class			0.0652
A	6	1
B	8	9
C	6	10
Child-Pugh score1	8.6 ± 1.7	9.4 ± 1.8	0.135
MELD score1	8.0 ± 6.9	9.1 ± 5.1	0.582
Splenectomy	6	3	0.4513
Past esophageal or gastric varices	13	18	0.1273
Past gastrointestinal bleeding	12	18	0.0653
MPV thrombus			0.9382
Grade I	6	7
Grade II	13	11
Grade III	1	2
SMV thrombus	11	5	0.1053
SV thrombus	8	7	1.0003

¹Data are mean plus or minus standard deviation;

²Determined using Mann-Whitney U test;

³Determined using Fisher exact test. Data are numbers of patients. MELD: Model for end-stage liver disease; MPV: Main portal vein; SMV: Superior mesenteric vein, SV: Splenic vein.

Table 2 Comparison of portal vein thrombosis changes between the two groups

	SMA group (n = 20)			TIPS group (n = 20)
Time (mo)	6	12	24	6	12	24	P value
Recanalization	15	15	13	12	13	11	0.239 (6 mo)
Improved	4	4	4	4	2	3	0.307 (12 mo)
Stable	1	1	3	4	2	2	0.304 (24 mo)
Worse	0	0	0	0	3	4

Data are numbers of patients. Determined using Mann-Whitney U test. TIPS: Transjugular intrahepatic portosystemic shunt; SMA: Superior mesenteric artery.

Table 3 Changes in portal vein thrombosis before and after urokinase infusion in the superior mesenteric artery group

	Before	After	P value
MPV thrombus			< 0.001
Grade 0	0	13
Grade I	6	4
Grade II	13	3
Grade III	1	0
SMV thrombus	11	4	0.0481
SV thrombus	8	1	0.021

¹Determined using Fisher exact test. P value was obtained from a comparison at 24-mo follow-up. Data are numbers of patients. Determined using Mann-Whitney U test.

Table 4 Changes in portal vein thrombosis before and after transjugular intrahepatic portosystemic shunt in the transjugular intrahepatic portosystemic shunt group

	Before	After	P value
MPV thrombus			< 0.001
Grade 0	0	11
Grade I	7	3
Grade II	11	2
Grade III	2	4
SMV thrombus	5	7	0.7311
SV thrombus	7	3	0.2731

¹Determined using Fisher exact test. P value was obtained from a comparison at 24-mo follow-up. Data are numbers of patients. Determined using Mann-Whitney U test. SMA: Superior mesenteric artery; MPV: Main portal vein.