Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816 [PMID: 29085224 DOI: 10.3748/wjg.v23.i37.6802]
Corresponding Author of This Article
Rashmi Kaul, PhD, Associate Professor, Department of Biochemistry and Microbiology, Oklahoma State University-Center for Health Sciences, Tulsa, OK 74107, United States. rashmi.kaul10@okstate.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 7, 2017; 23(37): 6802-6816 Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6802
Table 1 Age ranges of normal and diseased subjects in whole tissue lysates
Group
No. of subjects
No. of females
Age range (yr)
No. of males
Age range (yr)
Normal
20
11
42-67
9
34-64
HCV
14
4
53-60
10
43-55
HCC
14
1
56
13
44-66
Table 2 Age ranges of normal and diseased subjects in mRNA analysis
Group
No. of subjects
No. of females
Age range (yrs)
No. of males
Age range (yrs)
Normal
9
8
42-67
1
64
HCV
10
3
43-60
7
43-53
HCC
10
0
N/A
10
44-59
Table 3 Age ranges of normal and diseased subjects in nuclear and cytoplasmic tissue lysates
Group
No. of subjects
No. of females
Age range (yr)
No. of males
Age range (yr)
Normal
10
5
43-67
5
50-64
HCV
12
3
51-60
9
46-53
HCC
16
0
NA
16
44-66
Table 4 Spearman correlations of ERα and ERβ expression in whole tissue lysates with nuclear cyclin D1, nuclear phosphorylated NF-κB and cytoplasmic phosphorylated IKK expression
Citation: Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816