Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease

Table 1 Recapitulative table with all included studies

Ref.	Arm1	Arm 2	Overall IBD type	Time of endoscopy
	Time to FD and LD to endoscopy	Time to FD and LD to endoscopy
Gould et al[23] 1982 (United Kingdom)	Castor oil 30 min (n = 23)	Senna 75 mg (n = 23)	RCH = 46	-
outpatient elective	LD: 24 h before	LD: 24 h before	CD = 0
Score: 3			Active disease = 7
Lazzaroni et al[12] 1993 (Italy)	PEG 4 L + placebo (n = 56)	PEG 4 L + simethicone 120 mg (n = 59)	RCH = 61	-
outpatient elective	FD: 2 L afternoon before	FD: 2L afternoon before	CD = 44
Score: 4	LD: 2 L 6 am day of	LD: 2L 6 am day of	Active disease = 0
Manes et al[13] 2015 (Italy)	PEG 4 L (n = 108)	PEG 2 L + bisacodyl 10 mg (n = 108)	RCH = 216	Between 8 am and 2 pm
outpatient elective	Whole dose (n = 48)	Whole dose (n = 35)	CD = 0
Score: 5	FD: 4 pm day before	FD: 4 pm day before	Active disease = 116
	Split dose (n = 60)	Split dose (n = 73)
	FD: 2 L day before	FD: 2 L day before
	LD: 2 L between 5 am and 7 am day of	LD: 2 L between 5 am and 7 am day of
Kim et al[24] 2017 (Korea)	PEG 4 L (n = 55)	PEG 2 L + ascorbate (n = 57)	RCH = 112	Between 9 am and 5 pm
outpatient elective	FD: 2 L 8 pm day before; LD: 2 L morning day of	FD: 2 L 8 pm day before, LD: 2 L morning day of	CD = 0
Score: 5	If colonoscopy scheduled in the afternoon, 4 L between 6 am and 8 am	If colonoscopy scheduled in the afternoon, 4 L between 6 am and 8 am	Active disease = 0

FD: First dose; LD: Last dose; IBD: Inflammatory bowel disease; PEG: Polyethylene glycol; CD: Crohn’s disease.

Table 2 Primary outcome: bowel cleanliness

	Numbers of studies	ITT patients	OR (95%CI)	Heterogeneity P value	I2
Primary outcome
Bowel cleanliness	2	325	1.19 (0.52-2.71)	0.27	19%
Secondary outcome
Willingness to repeat	2	320	5.11 (1.31-20.00)	0.03	78%
Procedure related outcome
Rates of cecal intubation	2	320	0.91 (0.32-2.53)	0.54	0%
Mayo endoscopic score = 0	2	320	1.09 (0.69-1.70)	0.38	0%
Mayo endoscopic score = 1	2	320	0.84 (0.54-1.33)	0.61	0%
Mayo endoscopic score = 2	1	109	1.17 (0.46-3.00)	-	-
Mayo endoscopic score = 3	2	320	2.89 (0.30-28.24)	1.00	0%
Side effects or complications
Flare of disease	1	109	0.62 (0.10-3.85)	-	-
Increase SCAII score	1	109	1.14 (0.47-2.75)	-	-
Dizziness	1	109	1.44 (0.23-9.00)	-	-
Abdominal pain/cramps	1	109	0.30 (0.03-3.01)	-	-
Bloating	1	109	0.72 (0.26-1.98)	-	-
Nausea	1	109	0.39 (0.16-0.94)	-	-
Vomiting	1	109	0.55 (0.17-1.81)	-	-
Insomnia	1	109	1.72 (0.70-4.23)	-	-

ITT: Intention-to-treat.