Clinicopathological, treatment, and prognosis study of 43 gastric neuroendocrine carcinomas

Table 1 Clinical characteristics of 43 gastric neuroendocrine carcinomas

Clinicopathological features	n (%)
Age (yr)
< 60/≥ 60	15 (34.88)/28 (65.12)
Mean ± SD	62.26 ± 10.46
Gender
Male/Female	35 (81.40)/8 (18.60)
Tumor location
Cardiac	21 (48.84)
Corpus	10 (23.26)
Antrum	10 (23.26)
Residual stomach anastomosis	2 (4.65)
Tumor size (max diameter, cm)
≤ 5/> 5	20 (46.51)/23 (53.49)
Mean ± SD	5.47 ± 3.18
T classification
T1	0 (0)
T2	4 (9.30)
T3	0 (0)
T4	39 (90.70)
Lymph node metastasis
N0/N1	12 (27.91)/31 (72.09)
Liver metastasis
Absent/present	37 (86.05)/6 (13.95)
Pathological stage
I/II/III/IV	0 (0)/2 (4.65)/35 (81.40)/6 (13.95)
Pathology
Small cell carcinomas	39 (90.70)
Large cell carcinomas	4 (9.30)
Operation
Curative resection	38 (88.37)
Palliative resection	5 (11.63)
Neoadjuvant therapy
No/present	100 (100)/0 (0)
Adjuvant chemotherapy
No-chemotherapy/present/lost	5 (11.63)/34 (79.07)/4 (9.30)
Follow-up
Median OS (mo)	31.0
Dead/alive/lost	23 (53.49)/17 (39.53)/3 (6.98)

Patients were staged in accordance with the 7^th Edition of the AJCC Cancer’s TNM Classification. OS: Overall survival.

Table 2 Univariable analysis of prognostic parameters for survival in Ren Ji cohort patients with gastric neuroendocrine carcinomas

Prognostic parameter	Univariable analysis
	HR	95%CI	P value
Age (yr)
< 60	1.0 (reference)
≥ 60	2.718	0.921-8.023	0.070
Gender
Male	1.0 (reference)
Female	0.915	0.308-2.718	0.873
Tumor location
Cardiac	1.0 (reference)
Corpus	3.034	1.100-8.374	0.032
Antrum	2.331	0.817-6.648	0.114
Residual stomach anastomosis	1.401	0.176-11.159	0.750
Tumor size
≤ 5 cm	1.0 (reference)
> 5 cm	1.605	0.693-3.717	0.269
T classification
T1 + T2	1.0 (reference)
T3 + T4	0.760	0.407-1.420	0.390
Lymph node metastasis
≤ 7	1.0 (reference)
> 7	2.766	1.101-6.948	0.030
Liver metastasis
Absent	1.0 (reference)
Present	3.515	1.269-9.731	0.016
Adjuvant chemotherapy
No-chemotherapy	1.0 (reference)
Present	0.226	0.076-0.674	0.008
Chemotherapy regimen
No-chemotherapy	1.0 (reference)
EP	0.138	0.029-0.667	0.014
EP + PTX	0.059	0.012-0.298	0.001
Other chemotherapy	0.426	0.140-1.296	0.133

The bold number represents the P values with significant differences. EP: Etoposide plus cisplatin; EP + PTX: EP plus Paclitaxel.