IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis

Table 1 Genotypes of the investigated IL23R single nucleotide polymorphisms in Hungarian population n (%)

SNP	Genotype	UC	Allele	UC
rs11209026	GG	109 (95.6)	G	223 (97.8)
	AG	5 (4.4)	A	5 (2.2)
	AA	0 (0.0)
	total	114
	RAF	0.0219
rs10889677	CC	51 (45.5)	C	155 (69.2)
	AC	53 (47.3)	A	69 (30.8)
	AA	8 (7.1)
	total	112
	RAF	0.308
rs1004819	GG	52 (40.3)	G	172 (66.7)
	AG	68 (52.7)	A	86 (33.3)
	AA	9 (7.0)
	total	129
	RAF	0.333
rs2201841	TT	58 (45.0)	T	176 (68.2)
	CT	60 (46.5)	C	82 (31.8)
	CC	11 (8.5)
	Total	129
	RAF	0.317
rs7517847	TT	40 (35.7)	T	136 (60.7)
	GT	56 (50.0)	G	88 (39.3)
	GG	16 (14.3)
	Total	112
	RAF	0.392
rs10489629	GG	44 (34.6)	G	155 (61.0)
	AG	67 (52.8)	A	99 (39.0)
	AA	16 (12.6)
	Total	127
	RAF	0.389
rs7530511	CC	94 (73.4)	C	220 (85.9)
	TC	32 (25.0)	T	36 (14.1)
	TT	2 (1.6)
	Total	128
	RAF	0.140

RAF: Risk allele frequency; SNP: Single nucleotide polymorphism; UC: Ulcerative colitis.

Table 2 IL23R single nucleotide polymorphisms with statistically significant influence on the clinical picture of ulcerative colitis

SNP	Wt vs Hz	Wt vs Ho	Wt vs Hz + Ho	Wt + Hz vs Ho	Total distribution
rs2201841
Montreal-classification	0.0429a	0.2270	0.1921	0.0217a	0.0084a
Iron deficiency	0.1892	0.1108	0.7476	0.0388a	0.0299a
Need for operation	0.0348a	1.0000	0.0766	0.6017	0.0564
rs7517847
Bowel movements	0.0050a	0.8183	0.0634	0.2979	0.0078a
rs10489629
Montreal classification	0.1017	0.3906	0.4445	0.1170	0.0405a
Weight loss	0.0652	0.0457a	0.0169a	0.1191	0.0350a
rs10889677
Azathioprine	0.0116a	0.3407	0.0136a	0.6113	0.0285a
Need for operation	0.0347a	0.8491	0.0746	0.6153	0.0595

Indicates significant difference (^aP < 0.05). Hz: Heterozygous; Ho: Homozygous; Wt: Wild type; Total distribution: Wt + Hz + Ho; SNP: Single nucleotide polymorphism.