Observation of the effect of targeted therapy of 64-slice spiral CT combined with cryoablation for liver cancer

Table 1 Postoperative ice coverage of different tumor sizes

Groups	Tumor diameter (cm)	Number of tumors (count)	ice coverage (%)			Effective rate
			100	80-99	< 80
Dual-slice group	< 3	38	19	12	7	81.58%
	≥ 3	27	17	8	2	92.59%
64-slice group	< 3	42	30	9	3	92.86%a
	≥ 3	35	26	7	2	94.29%

Effective rate = (ice coverage ≥ 80% of the tumor volume in the number of tumors)/(the total number of tumors) × 100%.

^aP < 0.05, vs the dual-slice group.

Table 2 Comparison of liver perfusion values before and after treatment (mean ± SD)

Tissue		64-slice group			Dual-slice group
		HAP(mL/min·100 mg)	PVP(mL/min·100 mg)	HAPI (%)	HAP(mL/min·100 mg)	PVP(mL/min·100 mg)	HAPI (%)
Tumor tissue	Pre-treatment	47.82 ± 16.71	8.51 ± 3.71	84.31 ± 13.22	48.42 ± 12.85	9.16 ± 3.75	82.27 ± 14.26
	Post-treatment	20.21 ± 9.42ac	8.13 ± 3.22	48.93 ± 9.42ac	26.21 ± 9.36a	8.53 ± 3.22	38.93 ± 9.42a
Adjacent tumor tissues	Pre-treatment	35.95 ± 15.25	47.81 ± 8.51	38.92 ± 16.91	35.95 ± 15.25	45.81 ± 8.51	37.92 ± 13.91
	Post-treatment	21.34 ± 9.95a	39.82 ± 14.33a	47.01 ± 9.71a	20.34 ± 9.95a	37.82 ± 14.33a	46.01 ± 9.71a
Normal liver tissue	Pre-treatment	25.65 ± 11.86	57.90 ± 18.93	28.62 ± 11.72	24.87 ± 13.48	58.93 ± 16.75	27.75 ± 14.68
	Post-treatment	26.02 ± 10.13	58.23 ± 16.94	27.43 ± 12.23	25.89 ± 10.78	59.78 ± 13.76	26.63 ± 12.25

^aP < 0.05, post-treatment vs pre-treatment in the group;

^cP < 0.05, vs the dual-slice group post-treatment. HAP: Hepatic artery perfusion; PVP: Portal vein perfusion; HAPI: Hepatic arterial perfusion index.

Table 3 Follow-up observation of treatment effect

Groups	Number of tumors (n)	Treatment effect (%)				Effective rate
		Complete ablation	Mostly ablated	Stable	Progressive
Dual-slice group	65	42 (64.62)	8 (12.31)	10 (15.38)	5 (7.69)	76.93%
64-slice group	77	62 (80.52)	9 (11.69)	4 (5.19)	2 (2.60)	92.21%
Test value	-	z = -2.325				χ2 = 8.946
P value	-	0.02				0.003%

Effective rate = (the number complete ablation cases + the number of mostly ablated cases)/ total number of tumors × 100%.

Table 4 Postoperative adverse reactions n (%)

Group	Number of cases	Fever	Pain	Skin frostbite	Nausea and vomiting	Pleural effusion	Intraperitoneal hemorrhage
Dual-slice group	56	33 (53.57)	5 (8.93)	1 (1.79)	5 (8.93)	3(5.36)	2(3.57)
64-slice group	68	43 (63.24)	7 (10.29)	1 (1.47)	6 (8.82)	0	0
χ2	-	1.925	0.106	0.032	0	5.508	3.635
P value	-	0.165	0.744	0.858	0.978	0.019	0.057