Chemotherapy response evaluation in a mouse model of gastric cancer using intravoxel incoherent motion diffusion-weighted MRI and histopathology

Table 1 Parameters of T2WI and intravoxel incoherent motion MR scanning

	T2WI	IVIM
Plane	Axial and coronal	Axial
TR (ms)	2800	2500
TE (ms)	72	42
Fat suppression	No	Yes
Matrix	256 × 192	64 × 64
FOV (mm2)	70 × 35	70 × 35
Thickness (mm)	1.5	1.5
Gap (mm)	0.5	0.5
		1 (b = 0-300)
NEX	4	2 (b = 400-600)
		4 (b = 800-1500)
b value (s/mm2)	NA	0, 10, 20, 30, 50, 80, 130, 200, 300, 400, 600, 800, 1000, and 1500

IVIM: Intravoxel incoherent motion.

Table 2 Median and interquartile range observed in intravoxel incoherent motion parameters, apparent diffusion coefficients and V_T values in the treated and control groups

		Day 0	Day 3	Day 7	Day 14	Day 21
VT (mm3)	Treated	219.96 (125.39-280.12)	356.88 (248.76-386.13)	368.33 (320.33-504.98)	559.3 (442.16-644.68)	439.7 (260.97-841.22)
	Control	157.1 (29.04-432.25)	281.71 (104.30-596.15)	476.34 (261.56-777.13)	938.64 (511.07-1345.82)	1515.24 (675.23-1856.48)
ADC (mm2/s)	Treated	0.57 (0.56-0.59)	0.62 (0.60-0.64)	0.62 (0.58-0.69)	0.83 (0.75-0.94)	0.72 (0.64-0.86)
	Control	0.61 (0.56-0.68)	0.57 (0.52-0.67)	0.55 (0.50-0.70)	0.65 (0.54-0.83)	0.77 (0.59-1.11)
D* (mm2/s)	Treated	1.99 (1.89-2.47)	1.4 (1.28-1.60)	1.58 (1.36-1.70)	1.68 (1.61-1.82)	1.68 (1.36-1.92)
	Control	2.07 (1.57-2.57)	2.23 (1.61-2.68)	1.97 (1.42-2.89)	2.25 (1.53-2.36)	1.81 (1.59-2.00)
fp (%)	Treated	19.15 (15.23-21.27)	32.90 (28.38-40.72)	37.19 (26.63-46.91)	49.95 (42.81-55.49)	42.56 (38.02-53.59)
	Control	22.38 (14.52-29.10)	22.98 (16.22-33.03)	22.47 (16.46-28.54)	27.87 (24.35-47.52)	40.2 (33.40-54.69)
D (mm2/s)	Treated	0.39 (0.37-0.41)	0.34 (0.29-0.37)	0.33 (0.23-0.36)	0.33 (0.29-0.35)	0.32 (0.23-0.38)
	Control	0.40 (0.33-0.44)	0.41 (0.33-0.44)	0.39 (0.33-0.47)	0.39 (0.32-0.47)	0.35 (0.32-0.44)

IVIM: Intravoxel incoherent motion; ADC: Apparent diffusion coefficients.