Prospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Jan 7, 2017; 23(1): 135-140
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.135
Table 1 Correlation of Crohn’s disease endoscopic activity assessed by Simple Endoscopic Score for Crohn’s disease with clinical and biochemical parameters recorded at the same time
Simple endoscopic score for Crohn’s disease vs biochemical parameters
CDAIAlbuminWBCPLTCRPHbFerritinFibrinogenESR
R value0.66-0.620.35000.44000.57-0.400.120.590.57
P value< 0.0001< 0.00010.00710.0005< 0.00010.00180.41< 0.0001< 0.0001
Table 2 Clinical, biochemical and demographic characteristics of Crohn’s disease patients with or without successful mucosal healing in response to anti-TNF-α therapy n (%)
FeatureAll (n = 29)MH-group (n = 18)Non-MH group(n = 11)MH vs non-MH
Change in Simple Endoscopic Score for Crohn’s disease over time (%)-55 [-72-(-37)]-70 [-81-(-56)]-33 [-38-(-8)]P < 0.0001
Age (yr)27 (21-35)22 (21-30)35 (27-39)P = 0.02
Men21 (72)15 (83)5 (45)P = 0.04
Disease duration (yr)6 (3-11)6 (5-10)6 (3-12)P = 0.77
Baseline Crohn’s disease Activity Index (n)319 (298-420)310 (240-397)348 (301-440)P = 0.26
Baseline Simple Endoscopic Score for Crohn’s disease (n)15 (8-21)16 (8-23)12 (8-20)P = 0.36
Baseline C-reactive protein (mg/L)9.8 (2.8-31.2)8.7 (2.3-18.2)18.6 (3.7-34.5)P = 0.15
Baseline hemoglobin (g/dL)12.9 (10.1-14)12 (9.9-13.5)13.1 (10.2-14.8)P = 0.60
Baseline albumin (mg/dL)4.2 (3.6-4.4)4.1 (3.5-4.4)4.2 (3.7-4.4)P = 0.84
Disease location
L1 (ileal)3/29 (10)1/18 (5)2/11 (18)P = 0.53
L2 (colonic)9/29 (31)5/18 (28)4/11 (36)P = 0.69
L3 (ileocolonic)17/29 (59)12/18 (67)5/11 (46)P = 0.43
Disease behavior
B1 (inflammatory)24/29 (83)14/18 (78)10/11 (91)P = 0.62
B2 (stricturing)1/29 (3)1/18 (5)0/11 (0)P = 1.00
B3 (penetrating)4/29 (14)3/18 (17)1/11 (9)P = 1.00
Medications
Steroids19/29 (65)10/18 (55)9/11 (82)P = 0.23
Azathioprine15/29 (52)12/18 (67)3/11 (27)P = 0.06
Aminosalicylates28/29 (96)18/18 (100)10/11 (91)P = 0.37
Anti-TNF-α agent used: adalimumab/infliximab17/12 (59/41)11/7 (61/39)6/5 (55/45)P = 0.51