Epigenetic regulation of insulin-like growth factor axis in hepatocellular carcinoma

Table 1 microRNAs that regulate key players of the insulin-like growth factor axis in hepatocellular carcinoma

Downstream IGF member	Upstream microRNAs	Net effect on IGF member expression
IGF-I	miR-190b	Downregulated
	miR-486-5p	Upregulated
IGF-II	miR-615-5p
	Let-7a	Downregulated
	miR-96
	miR-182	Upregulated
	miR-155
IGFBPs:	miR-17-5p	Downregulated
IGFBP3
IGF-1R	miR-145
	miR-122
	miR-99a
	miR-223	Downregulated
	miR-486-5p
	miR-182
	miR-1275
	miR-181a
	miR-96
	miR-155	Upregulated
IGF-2R	miR-211	Downregulated

IGF: Insulin-like growth factor.