Retrospective Study
Copyright ©The Author(s) 2016.
World J Gastroenterol. Nov 7, 2016; 22(41): 9196-9204
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9196
Table 1 Demographics of patients and lesions, n
Number of patientsn= 147
Age (yr), median (range)67 (39-86)
Male, n (%)130 (88%)
History of cancers (head and neck/esophagus)85/74
Drinking history
Number of drinkers134
Drinking duration (yr), median (range)40 (10-68)
Number of flushers102
Smoking history
Number of smokers129
Smoking (yr), median (range)35 (3-70)
Number of lesions89
Diameter of lesions (mm), median (range)15 (4-100)
Histology (SCC/HGIN/LGIN/inflammation)48/6/27/8
Superficial esophageal squamous cell carcinoma (including HGIN)54
Diameter (mm), median (range)19 (4-100)
Macroscopic type; n, (0-I/0-IIa/0-IIb/0-IIc /0-III)5/2/25/21/1
Depth of invasion; n, (HGIN/EP, LP/MM- SM1/SM2/unknown1)3/29/7/3/12
Treatment; n, (ER/SR/CRT/others)32/11/5/6
Table 2 The results of the univariate analysis of the Narrow Band Imaging combined with magnifying endoscopy findings for the diagnosis of superficial esophageal squamous cell carcinoma, n (%)
NBI-ME findingsEsophagitisLGINSESCCOdds ratio (95%CI)P value
(n = 8)(n = 27)(n = 54)
IBC1 (13)19 (70)45 (83)3.3 (1.2-8.9)NS
Proliferation3 (38)21 (78)50 (93)5.0 (1.4-17.5)< 0.01
Dilatation3 (38)20 (74)48 (89)3.6 (1.2-11.1)NS
Tortuosity2 (25)14 (52)44 (81)5.2 (2.0-13.6)< 0.01
Change in caliber2 (25)6 (22)31 (57)4.5 (1.7-11.8)< 0.01
Various shapes3 (38)14 (52)46 (85)5.4 (2.0-14.8)< 0.01
Table 3 Diagnostic performance of each criteria
Brownish area aloneSimplified dyad criteriaP value
(95%CI)(95%CI)
Sensitivity92.6% (82.1-97.9)77.8% (64.4-88.0)NS1
Specificity8.57% (1.8-23.1)57.1% (39.4-73.7)P < 0.012
Overall accuracy59.6% (48.6-69.8)69.7% (59.0-79.0)NS1