HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer

doi:10.3748/wjg.v22.i41.9141

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2016; 22(41): 9141-9153
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9141

Table 1 Correlation between expressions of human epidermal growth factor receptor 2, phospho-Thr183 and Tyr185-c-Jun N-terminal kinase and phosphor-Ser473-protein kinase B in human gastric cancer specimens

	HER2 (n)		Total
	Positive	Negative
Total	56	367	423
pJNK
Positive	24	106	130
Negative	32	261	293
pAKT
Positive	9	27	36
Negative	7	340	347
	pJNK (n)		Total
	Positive	Negative	Total
Total	130	293	423
pAKT
Positive	17	19	36
Negative	113	274	387

^aP value was statistically significant. HER2: Human epidermal growth factor receptor 2; pJNK: Phospho-Thr183 and Tyr185-c-Jun N-terminal kinase; pAKT: Phosphor-Ser473-protein kinase B.

Citation: Choi Y, Ko YS, Park J, Choi Y, Kim Y, Pyo JS, Jang BG, Hwang DH, Kim WH, Lee BL. HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. World J Gastroenterol 2016; 22(41): 9141-9153
URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9141.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9141