Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME

doi:10.3748/wjg.v22.i41.9127

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2016; 22(41): 9127-9140
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9127

Table 1 Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis

Medication (/kg) given ip (once time daily) or continuously in drinking water (po) after the creation of esophagogastric anastomosis in rats	Esophagitis score (0-5) Min/Med/Max in rats that underwent esophagogastric anastomosis
	1 d	2 d	3 d	4 d
	Min/Med/Max	Min/Med/Max	Min/Med/Max	Min/Med/Max
Saline 5 mL	4/4/4	4/4/4	4/4/4	4/4/4
BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg	5/5/5^a	5/5/5^a	5/5/5^a	5/5/5^a
L-arginine 100 mg	0/1/2^a	1/2/3^a	1/2/3^a	1/2/3^a
L-NAME 5 mg + L-arginine 100 mg	2/3/4^a	0/1/2^a	1/2/3^a	1/2/3^a
L-NAME 5 mg + BPC 157 10 μg	1/2/3^a	1/2/3^a	0/1/2^a	0/1/2^a
L-arginine 100 mg + BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 μg	0/1/2^a	0/1/2^a	1/2/3^a	0/1/2^a
BPC 157 10 ng	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + BPC 157 10 ng	1/2/3^a	2/3/4^a	1/2/3^a	0/1/2^a
L-arginine 100 mg + BPC 157 10 ng	0/1/2^a	0/1/2 ^a	0/1/2^a	0/1/2^a
L-NAME 5 mg + L-arginine 100 mg +BPC 157 10 ng	1/2/3^a	0/1/2^a	1/2/3^a	0/1/2^a
Drinking water	4/4/4	4/4/4	4/4/4	4/4/4
12 mL/d per rat
BPC 157 10 μg	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a
BPC 157 10 ng	0/1/2^a	0/1/2^a	0/1/2^a	0/1/2^a

Medication (/kg) given intraperitoneally (ip) (once daily) or continuously in drinking water (po) after the creation of an esophagogastric anastomosis in rats. BPC 157 10 μg and 10 ng, L-NAME 5 mg, and L-arginine 100 mg given alone and/or combined intraperitoneally with the first application at 30 min after anastomosis creation and the last at 24 h before sacrifice. Drinking water alone (12 mL/d per rat) or BPC 157 in drinking water (10 μg, 10 ng/kg; 0.16 μg, 0.16 ng/mL) was provided continuously until sacrifice.

^aP < 0.05, at least vs control.

Citation: Djakovic Z, Djakovic I, Cesarec V, Madzarac G, Becejac T, Zukanovic G, Drmic D, Batelja L, Zenko Sever A, Kolenc D, Pajtak A, Knez N, Japjec M, Luetic K, Stancic-Rokotov D, Seiwerth S, Sikiric P. Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME. World J Gastroenterol 2016; 22(41): 9127-9140
URL: https://www.wjgnet.com/1007-9327/full/v22/i41/9127.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i41.9127