Liver grafts from hepatitis B surface antigen-positive donors: A review of the literature

Table 1 Published studies with liver transplantation using hepatitis B surface antigen (+) positive donors in hepatitis B surface antigen (+) recipients

Ref.	Patient No.	Prophylaxis		Outcome at the last FU			MedianFU (mo)
		Nucleos(t)ide	HBIg	HBV disease	HBsAg	HBV-DNA
		Analogue
Franchello et al[13]	3	LMV	Yes	No (n = 1)	Persistence	Negative	19
		LMV + ADV (n = 1)		Yes (HDV =2)		HDVRNA +
Ho et al[17]	1	LMV + ADV	No	No	Persistence	Negative	24
Hwang et al[16]	1	LMV + ADV	Yes	Mild	Persistence	Negative	64
Soejima et al[15]	1	LMV	Yes	No	Persistence	Negative	48
Jiao et al[24]	2	LMV	Yes	Mild	Persistence	Negative	48
Jang et al[25]	6	LMV + ADV	Yes	No	Persistence	Negative	22.5
Bahde et al[14]	1	LMV + ADV	Yes	HDV cirrhosis	Persistence	Negative	50
						HDVRNA +
Loggi et al[23]	6	LMV + ADV	Yes	No	Persistence	Negative	42
		LMV + TDF
Choi et al[26]	8	LMV (n = 2)	Yes	No	Persistence (n = 6)	Negative	25.5
		ETV (n = 6)			Loss (n = 2)
Ju et al[27]	23	ETV	Yes	No	Persistence (n = 17)	Negative	NA
					Loss (n = 1)
Saidi et al[28]	68	NA	NA	NA	NA	NA	NA
Li et al[29]	15	NA	NA	NA	NA	NA	NA
Yu et al[31]	38	Not specified	Yes	No	Persistence	Negative	NA
Jeng et al[32]	13	ETV	No	No	Persistence	Negative	46

In HDV-coinfected recipients. HBIg: Hepatitis B immunoglobulins; LMV: Lamivudine; ADV: Adefovir; TDF: Tenofovir; ETV: Entecavir; FU: Follow-up; NA: Not available.

Table 2 Published studies with liver transplantation using hepatitis B surface antigen (+) positive donors in hepatitis B surface antigen (-) recipients

Ref.	Patient No.	Etiology of liver disease	Prophylaxis		Outcome at the last FU			Median FU (mo)
			Nucleos(t)ide	HBIg	HBV disease	HBsAg	HBV-DNA
			Analogue
Gonzalez et al[12]	1	Crypto	NO	Yes	Mild	Negative	Negative	24
Loggi et al[22]	1	HBV	LMV	No	No	Negative	Negative	18
Loggi et al[23]	4	HCV (n = 3)	LMV	Yes	Mild	Negative	Negative	42
		PBC (n = 1)	LMV + ADV					(12-60)
Saidi et al[28]	24	NA	NA	NA	Survival similar to controls	NA	NA	NA
Li et al[29]	63	HCV (n = 34)	NA	NA	Survival similar to controls	NA	NA	NA
		NASH (n = 2)
		Alcohol (n = 6)
		Other (n = 17)
Krishnamoorthi et al[30]	15	NA	NA	NA	Survival similar to controls	NA	NA	NA
Yu et al[31]	4	NA	NA	NA	Survival similar to controls	NA	NA	NA
Jeng et al[32]	1	HCV	ETV	No	No	Negative	Negative	12

Crypto: Cryptogenetic HBV cirrhosis; PBC: Primary biliary cirrhosis; NASH: Nonalcoholic steatohepatitis; FU: Follow-up; NA: Not available.