Isolated splenic metastasis from colon cancer: Case report

Table 1 Characteristic of patients, their primary tumors, therapeutics and outcomes in the cases reports of isolated splenic metastasis from colorectal carcinoma

Case No.	Ref.	Age, sex	Primary tumor	Stage (LN)	Size (cm)	CEA (ng/mL)	Imaging	Treatment1	1st DFI (mo)	2nd DFI (mo)
1	Dunbar et al[3], 1969	F, 78	Rectum	III(+)	18	64.0	CT	S	48	84
2	Waller et al[4], 1982	M, 72	Sigmoid	III(+)	9	106.0	LSS	S	48	6
3	Slavin et al[5], 1986	M, 81	Cecum	III(+)	NL	7.5	LSS	S	30	12
4	Capizzi et al[6], 1992	F, 51	Rectum	II(-)	NL	13.5	CT	S	51	14
5	Thomas et al[7], 1993	F, 72	Descending	II(-)	3	223.0	CT	S	144	12
6	Mainprize et al[8], 1997	F, 62	Descending	III(+)	4	High	CT	S	42	12
7	Indudhara et al[9], 1997	M, 74	Sigmoid	II(-)	9.5	23.4	CT	S	24	24
8-11	Ishida et al[10], 199	F, 73	Ascending (3 cases)	IV(NL)	1.5-7.5 (all cases)	NL	CT	S	Syn	72
		M, 62	Splenic flexure (1 case)	IV(NL)		NL	CT	S	Syn	24
		M, 52		NL		NL	US and CT	S	12	6
		M, 48		NL		NL	US and CT	S	24	3
12	Weathers et al[11], 1999	F, 33	Sigmoid	III(+)	3.5	9.0	CT and MRI	S	3	12
13	Kim et al[12], 2000	M, 65	Ascending	III(+)	5	14.9	CT	S	36	18
14	Lee et al[13], 2000	F, 60	NL	NL	NL	High	CT	S	108	5
15	Place[14], 2001	M, 51	Sigmoid	III(+)	13	5.0	CT	S	72	6
16	Okuyama et al[15], 2001	M, 62	Sigmoid	III(+)	3	N	US and CT	S	24	23
17	Avesani et al[16], 2001	F, 52	Descending	IV(-)	5	High	CT	S	Syn	12 relapse
18	Cavallaro et al[17], 2004	F, 55	Sigmoid	III(+)	3	N	CT and PET	S	21	12
19	Hiraiwa et al[18], 2006	F, 49	Ascending	IV(+)	NL	36.7	CT	S	Syn	24 relapse
20	Avninder et al[19], 2006	M, 52	Sigmoid	IIA(-)	13	7.2	US and CT	Cmt, S	108	22
21	Gencosmanoglu et al[20], 2006	M, 76	Descending	III(+)	6.5	High	CT and PET	S, Cmt	17	12
22	Pisanu et al[21], 2007	F, 54	Splenic flexure	IV(-)	4.5	High	CT	S, Cmt	Syn	6 relapse
23	Popović et al[22], 2008	M, 72	Rectum	III(+)	NL	High	CT	S	18	NL
24	Bigot et al[24], 2008	F, 69	Sigmoid	II(-)	4	High	CT	S	24	60
25	Gasent Blesa et al[25], 2008	F, 52	Descending	III(+)	4.5	High	PET	S	36	NL
26	Montemurro et al[23], 2008	F, 80	Transverse	III(+)	8	52.0	CT	S, TT	9	6
27	Sileri et al[26], 2009	M, 73	Hepatic flexure	II(-)	1.5	High	CT-PET	S	60	40
28	Busić et al[27], 2010	M, 70	Splenic flexure	III(+)	8	High	CT US	S	24	12
29	Genç et al[28], 2010	M, 59	Ascending	III(+)	4	37.0	CT	S	15	24
30	Dogan et al[29],2010	M, 58	NL	II(-)	3.5	4.62	CT	S, Cmt	20	11 relapse
31	Pavlović et al[30], 2011	M, 78	Cecum	III(+)	7	38.6	CT, PET	Cmt, S	37	9 relapse
32	Our case, 2015	F, 64	Cecum	I(-)	4.9	38.0	CT	S	16	6 relapse

¹Spleen metastases; 1^st DFI disease-free interval between treatment of primary tumor and diagnosis of the spleen metastasis; 2^nd DFI disease- free interval after splenectomy. CEA: Carcinoembrionic antigen; N: Normal; LN: Lymph node; NL: Not listed; CT: Computed tomography; US: Ultrasonography; LSS: Liver splenic scintigraphy; PET: Positron emission tomography; MRI: Magnetic resonance imagery; S: Surgery; Cmt: Chemotherapy; TT: Target therapy.