Copyright ©The Author(s) 2016.
World J Gastroenterol. Apr 7, 2016; 22(13): 3679-3686
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3679
Table 1 Characteristics of studies included in the analysis
AuthorDesignPopulationDefinition of IBDDrugexposureExclusioncriteriaNo. of patientsOR (95%CI)1Adjustment/matchingNOS quality assessment
Bansal et al[42], 1996Case-controlUS veterans affairsClinical databaseNSAID associated diagnosisNot specified114460.84 (0.65-1.09)Adjusted for age, sex and ethnicity6
Eaden et al[38], 2000Case-controlUK HospitalClinical, pathological and radiological recordsPrescribed 5-10 years before diagnosisColorectal surgery, IBD diagnosed at time of cancer diagnosis2060.80 (0.21-2.98) AspirinNon-adjusted4
Van Staal et al[14], 2005Nested case-controlUK general practiceClinical recordsPrescribed in the 6 mo prior to diagnosisColorectal surgery, previous history of CRC7001.52 (0.7-3.25) (Aspirin)Non-adjusted5
0.80 (0.38-1.66) (NA-NSAID’s)
Velayos et al[39], 2006Case-controlUS HospitalClinical, pathological and endoscopic records2 records of use in notesPrevious CRC, IBD diagnosed at same time as CRC, incomplete data3760.3 (0.1-0.8) (Aspirin)Matched on gender, duration of disease and extent of disease8
0.1 (0.03-0.5) (NA-NSAID)
Terdiman et al[40], 2007Case-controlUS insurance claimsClinical recordsPrescribed in the year before diagnosisColorectal surgery15360.97 (0.74-1.28)Non-adjusted5
Tang et al[43], 2010Retrospective cohortUS HospitalClinical databaseEver usedNo colonic involvement of IBD480.29 (0.03-2.75)Non-adjusted5
Samadder et al[41], 2011Case-controlN. Israel communityPatient questionnairesWeekly for > 3 yrPrevious history of CRC600.49 (0.07-3.32)Matched for age, gender and ethnicity6
Baars et al[44], 2011Case-controlNetherlands nationwide pathologyPathology reportsEver usedIBD diagnosed at the same time as CRC5511.96 (0.72-5.36)Non-adjusted6
Rubin et al[45], 2013Case-controlUS HospitalPathology reportsNot specifiedIncomplete records2001.84 (0.75-2.5)Non-adjusted5
Table 2 Subgroup analyses for studies reporting on risk of colorectal cancer in patients with inflammatory bowel disease taking non-aspirin non-steroidal anti-inflammatory drugs
No. of studiesPooled OR (95%CI)
Matched y/n
Matched/adjusted30.47 (0.18-1.13)
None51.04 (0.65-1.43)
Study location
Hospital60.92 (0.78-2.62)
Population20.88 (0.72-1.04)