Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

doi:10.3748/wjg.v22.i12.3363

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 28, 2016; 22(12): 3363-3371
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3363

Table 1 Body weight, vasopressin and serum sodium in baseline conditions in cirrhotic rats prior to receiving tolvaptan (3 mg/kg), tolvaptan (5 mg/kg) or vehicle

		1 d	2 d	3 d	4 d	5 d
Body weight (g)	Vehicle	486.7 ± 12.57 (5)	492.1 ± 10.12 (5)	472.8 ± 18.21 (5)	475.2 ± 9.21 (5)	482.8 ± 13.24 (5)
	Tolvaptan (3 mg/kg)	502.3 ± 11.91 (6)	487.3 ± 12.43 (6)	465.6 ± 16.59 (6)	465.6 ± 13.24 (6)	476.3 ± 16.00 (5)
	Tolvaptan (5 mg/kg)	493.4 ± 16.34 (6)	485.2 ± 20.21 (6)	490.1 ± 13.12 (6)	472.1 ± 12.12 (6)	490.1 ± 11.12 (6)
Vasopressin(pg/L)	Vehicle	13.25 ± 1.24 (5)	14.15 ± 1.41 (5)	15.44 ± 1.38 (5)	14.99 ± 0.94 (5)	13.05 ± 0.85 (5)
	Tolvaptan (3 mg/kg)	15.29 ± 0.93 (6)	13.37 ± 1.22 (6)	16.87 ± 0.73 (6)	15.16 ± 1.17 (6)	14.33 ± 0.99 (5)
	Tolvaptan (5 mg/kg)	14.85 ± 1.39 (6)	14.23 ± 0.81 (6)	15.12 ± 1.21 (6)	13.21 ± 1.21 (6)	15.23 ± 0.81 (6)
Serum sodium (mol/L)	Vehicle	141.2 ± 1.31 (5)	141.2 ± 1.11 (5)	139.2 ± 0.75 (5)	140.1 ± 0.92 (5)	140.2 ± 1.31 (5)
	Tolvaptan (3 mg/kg)	139.2 ± 1.27 (6)	141.3 ± 1.20 (6)	138.2 ± 1.85 (6)	140.1 ± 1.23 (6)	138.2 ± 1.87 (5)
	Tolvaptan (5 mg/kg)	141.2 ± 1.21 (6)	140.9 ± 1.12 (6)	142.2 ± 1.22 (6)	138.1 ± 2.21 (6)	139.1 ± 1.55 (6)

Data are mean ± SEM (number of rats); no significant difference was found between different doses of tolvaptan and vehicle.

Table 2 Body weight, vasopressin, and serum sodium in cirrhotic rats after tolvaptan (3 mg/kg), tolvaptan (5 mg/kg), or vehicle

		1 d	2 d	3 d	4 d	5 d
Body weight (g)	Vehicle	492.6 ± 11.22 (5)	498.5 ± 12.21 (5)	490.3 ± 16.21 (5)	500.1 ± 16.21 (5)	493.1 ± 11.12 (5)
	Tolvaptan (3 mg/kg)	482.2 ± 20.21 (5)	466.2 ± 10.19 (6)^a	450.1 ± 18.21 (5)^a	443.1 ± 20.12 (6)^a	440.1 ± 20.12 (5)^a
	Tolvaptan (5 mg/kg)	460.2 ± 12.31 (5)^a	455.1 ± 16.12 (5)^a	440.2 ± 23.12 (6)^a	437.3 ± 22.21 (5)^a	446.1 ± 21.21 (4)^a
Vasopressin (pg/L)	Vehicle	12.97 ± 0.92 (5)	13.81 ± 1.30 (5)	15.91 ± 0.89 (5)	16.97 ± 1.38 (5)	14.02 ± 0.98 (5)
	Tolvaptan (3 mg/kg)	12.25 ± 0.82 (5)	11.41 ± 0.62 (6)	10.21 ± 0.91 (5)^a	9.77 ± 1.21 (6)^a	7.12 ± 1.32 (5)^b
	Tolvaptan (5 mg/kg)	12.01 ± 1.21 (5)	10.12 ± 0.92 (5)^a	8.12 ± 1.22 (6)^a	7.01 ± 1.63 (5)^b	7.33 ± 1.13 (4)^a
Serum sodium (mol/L)	Vehicle	140.2 ± 1.25 (5)	140.2 ± 1.51 (5)	141.2 ± 0.65 (5)	141.1 ± 1.61 (5)	142.2 ± 0.81 (5)
	Tolvaptan (3 mg/kg)	143.2 ± 2.32 (5)	144.2 ± 1.17 (6)^a	146.1 ± 1.13 (5)^a	147.2 ± 2.11 (6)^b	146.1 ± 2.47 (5)^a
	Tolvaptan (5 mg/kg)	144.1 ± 1.22 (5)^a	147.1 ± 2.51 (5)^a	147.9 ± 2.21 (6)^a	146.2 ± 1.71 (5)^a	147.2 ± 1.12 (4)^b

Data are mean ± SEM (number of rats);

^aP < 0.05, tolvaptan vs vehicle, respectively;

^bP < 0.01, tolvaptan vs vehicle, respectively.

Citation: Chen C, Chen RP, Lin HH, Zhang WY, Huang XL, Huang ZM. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol 2016; 22(12): 3363-3371
URL: https://www.wjgnet.com/1007-9327/full/v22/i12/3363.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i12.3363