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Copyright ©The Author(s) 2015.
World J Gastroenterol. Feb 28, 2015; 21(8): 2315-2322
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2315
Table 1 Conventional pharmacological treatments for irritable bowel syndrome
Drug categoryDrug functionsExamples
AntispasmodicsAntagonists of muscarinic receptors and calcium channels of smooth musclePinaverium bromide, mebeverine, trimebutine maleate
Antidiarrhealsμ-opioid receptors agonistsLoperamide
LaxativesOsmotic, stimulantBisacodyl, polyethylene glycol, lactulose
Bulking agentsWater binding to increase stool bulkMethylcellulose, psyllium
Receptor targeted5-HT3 receptor antagonistsAlosetron, cilansetron
5-HT4 receptor agonistsMetoclopramide, domperidone
ProbioticsTo balance intestinal floraLactobacilli, bifidobacteriae
PsychiatricsTricyclic antidepressantsAmitriptyline, doxepin
Selective serotonin reuptake inhibitorsCitalopram, fluoxetine
AntibioticsTo inhibit gut microorganismsNeomycin, rifaximin