Copyright ©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 12190-12196
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12190
Table 1 Reported major liver cancer stem cell markers
MarkerOriginMinimum tumorigenic cellsClinical relevant characteristicsRelated literature
CD133HuH7 cell,SMMC-7721 cell1 × 102-1 × 103With a poor prognosis;Related with invasiveness and distant metastases;Resistance to chemotherapy drugs[14,15,17,48,59]
CD90PLC cell,MHCC-97L,HCC tumor,blood samples of 90% patients with liver cancer5 × 102Related with tumorigenic ability and metastasis of liver cancer[23,24]
EpCAMHuH1 cell,HuH7 cell1 × 103The origin of recurrence and metastasis postoperatively;Patients with vascular metastasis and low overall survival rate when peripheral circulation exists[31]
OV6SMMC-7721 cell5 × 103Drugs resistance;Strong metastasis and invasion[39]
CD441MHCC-LM3 cell,MHCC-97L cell1 × 102Chemotherapy drug resistance;Related with portal vein metastasis in liver cancer[41]
SP (ABCG2)Huh7 cell,PLC/PRF/5 cell1 × 103-[46,60]