Role of phytochemicals in colorectal cancer prevention

Table 1 Current clinical trials of curcumin and resveratrol

ClinicalTrials.gov Identifier	Title	Design/phase	Intervention	Primary purpose
NCT01294072	Study investigating the ability of plant exosomes to deliver curcumin to normal and colon cancer tissue	Phase I	Dietary supplement: curcumin Dietary supplement: curcumin conjugated with plant exosomes Other: no intervention	Treatment
NCT00295035	Phase III trial of gemcitabine, curcumin and celebrex in patients with metastatic colon cancer	Phase III	Drug: celecoxib Drug: curcumin	Treatment
NCT00027495	Curcumin for the prevention of colon cancer	Phase I	Dietary supplement: curcumin	Prevention
NCT00973869	Curcumin in preventing colorectal cancer in patients undergoing colorectal endoscopy or colorectal surgery	Phase I	Dietary supplement: curcumin Other: high performance liquid chromatography Other: laboratory biomarker analysis Other: pharmacological study Procedure: diagnostic endoscopic procedure Procedure: therapeutic conventional surgery	Prevention
NCT00365209	Phase IIA trial of curcumin among patients with prevalent subclinical neoplastic lesions (aberrant crypt foci)	Phase II	Other: laboratory biomarker analysis Other: pharmacological study Drug: curcumin	Prevention
NCT01490996	Combining curcumin with FOLFOX chemotherapy in patients with inoperable colorectal cancer	Phase I Phase II	Drug: oral complex C3 curcumin+ chemotherapy Drug: chemotherapy only	Treatment
NCT01859858	A prospective evaluation of the effect of curcumin on dose limiting toxicity and pharmacokinetics of irinotecan in patients with solid tumors	Phase I	Dietary supplement: curcumin Drug: Irinotecan	Basic science
NCT00118989	Curcumin for the chemoprevention of colorectal cancer	Phase II	4 g curcumin daily for 4 mo or placebo	Prevention
NCT00256334	Resveratrol for patients with colon cancer	Phase I	Drug: resveratrol	Treatment
NCT00578396	Phase I biomarker study of dietary grape-derived low dose resveratrol for colon cancer prevention	Phase I	Dietary supplement: grapes	Prevention Phase I
NCT00433576	Resveratrol in treating patients with colorectal cancer that can be removed by surgery	Phase I	Patients with colorectal adenocarcinomas received resveratrol for days 1 to 8 and on day 9 underwent colorectomy Tumor biopsy will be retrieved