Living donor liver transplantation with body-weight more or less than 10 kilograms

Table 1 The gender and age specific Z-scores of the measurements in height and weight in both groups

	< 10 kg (group 1) Z-score	>10 kg (group 2) Z-score
Male height	-3.364 (n = 51)	-2.43 (n = 53)
Male weight	-2.977 (n = 51)	-1.07 (n = 53)
Female height	-3.266 (n = 50)	-1.504 (n = 42)
Female weight	-3.277 (n = 50)	-0.046 (n = 42)

The calculation of Z-score follows that used by the National Health and Nutrition Examination Survey (NHANES) 2000[14].

Table 2 Patients’ characteristics between groups

	G1 (n = 101)	G2 (n = 95)	P value
Age (mo)	16.1± 25.1	67.6 ± 49.1	< 0.001
Weight (kg)	7.8 ± 1.2	18.6 ± 11.2	< 0.001
Height (cm)	69.6 ± 6.0	103.1 ± 23.9	0.006
PELD score	15.9 ± 10.9	6.8 ± 8.9	< 0.001
Hemoglobin (g/dL)	9.2 ± 1.7	10.0 ± 1.7	0.003
Serum albumin (g/L)	3.1 ± 0.6	3.5 ± 0.7	< 0.001
Serum creatinine (mg/dL)	0.8 ± 0.3	0.7 ± 0.14	0.113
Total bilirubin	18.4 ±11.0	8.4 ± 9.3	< 0.001
INR	1.45 ± 0.8	1.07 ± 0.2	< 0.001
APTT (S)	44.4 ± 18.9	37.3 ± 13.2	0.001
Platelet (1000/μL)	191.0 ± 110	163.1 ± 117	0.015

PELD: Pediatric end stage liver disease; INR: International normal ratios; APTT: Activated partial thromboplastine times; G1: Those with body weights of less than 10 kg were included in group 1; G2: Those with weights of more than 10 kg were included in group 2.

Table 3 Anesthesia time, intraoperative blood loss and fluids replacement

	G1 (n = 101)	G2 (n = 95)	P value
Anesthesia time (h)	13.5 ± 9.3	13.3 ± 2.2	0.035
Blood loss (mL)	215.3 ± 238.8	284.8 ± 447.8	0.573
Blood loss (mL/kg)	28.6 ± 36.7	15.0 ± 21.2	< 0.001
Ascites (mL/kg)	234 ± 379	161.3 ± 383	< 0.001
Crystalloid (mL/kg/h)	16.8 ± 5.5	12.1 ± 5.5	< 0.001
Red blood cells (mL/kg)	29.0 ± 29.0	10.0 ± 17.3	< 0.001
Fresh frozen plasma (mL/kg)	1.5 ± 7.6	5.1 ± 11.0	0.571
5% Albumin (mL/kg)	8.8 ± 6.8	2.3 ± 2.0	< 0.001
Sodium bicarbonate (mEq/kg)	3.4 ± 1.9	2.3 ± 1.9	< 0.001
Calcium chloride (mg/kg)	0.7 ± 0.5	0.34 ± 0.3	< 0.001
Lasix administration (mg/kg)	0.5 ± 1.9	1.0 ± 2.9	0.884
Cold ischemic time (min)	58.6 ± 20.5	65.5 ± 29.1	0.243
Warm ischemic time (min)	49.5 ± 13.9	47.6 ± 14.9	0.226

P < 0.05 was regarded as significant. G1: those with body weights of less than 10 kg were included in group 1; G2: those with weights of more than 10 kg were included in group 2.

Table 4 Intra- and postoperative laboratory data between groups

	G1 (n = 101)	G2 (n = 95)	P value
pH - after anesthesia	7.34 ± 0.07	7.36 ± 0.07	0.060
pH - dissection	7.27 ± 0.06	7.30 ± 0.07	0.003
pH - anhepatic	7.26 ± 0.06	7.29 ± 0.10	0.013
pH - reperfusion	7.23 ± 0.06	7.27 ±.09	0.006
pH - end of surgery	7.28 ± 0.07	7.29 ± 0.08	0.215
INR post-operation	2.1 ± 1.0	1.9 ± 0.6	0.900
APTT post-operation (second)	77.2 ± 25.5	55.2 ± 20.9	< 0.001
Platelet post-operation (1000/μL)	109.5 ± 62.9	128.3 ± 74.6	0.070
Postoperative hemoglobin (g/dL)	7.6 ± 1.3	8.5 ± 1.5	0.001
Hemoglobin at extubation (g/dL)	8.2 ± 1.5	8.8 ± 1.5	0.072
Extubation time (h)	61.1 ± 243.5	23.6 ± 36.0	0.047

INR: International normal ratios; APTT: Activated partial thromboplastine times; G1: Those with body weights of less than 10 kg were included in group 1; G2: Those with weights of more than 10 kg were included in group 2.

Table 5 Comparison of the morbidity and mortality between groups

	G1 (n = 101)	G2 (n = 95)	P value
Bile duct complication	5	7	0.528
Hepatic artery complication	9	3	0.092
Hepatic vein complication	2	6	0.274
Portal vein complication	12	1	0.001
Reopen	19	13	0.324
One-year survival rate (%)	95.9	96.8	0.515
Three-year survival rate (%)	94.9	94.6	0.515

G1: those with body weights of less than 10 kg were included in group 1; G2: those with weights of more than 10 kg were included in group 2.