Antimicrobial prophylaxis in patients with colorectal lesions undergoing endoscopic resection

Table 1 Clinical characteristics of inpatients, lesions and treatment modality n (%)

Characteristic	Antibiotic group(n = 107)	Control group(n = 107)	P value1
Age (yr)	68.1 ± 12.5 (42-86)	63.1 ± 9.5 (39-82)	0.7322
Gender (M:F)	62:45	68:39	0.421
Tumor size
< 10 mm	22 (20.5)	19 (17.8)	0.602
10-20 mm	60 (56.1)	65 (60.7)	0.488
> 20 mm	25 (23.4)	23 (21.5)	0.743
Macroscopic type
Pedunculated	14 (13.0)	16 (15.0)	0.694
Subpedunculated	32 (29.9)	30 (28.0)	0.763
Sessile	24 (22.4)	22 (20.6)	0.739
Flat elevated (0-IIa)	28 (26.2)	30 (28.0)	0.758
Flat (0-IIb, 0-IIc)	9 (8.5)	9 (8.5)	1.000
Location
Rectum and sigmoid	58 (54.2)	61 (57.0)	0.680
Descending	23 (21.5)	19 (17.8)	0.491
Transverse	12 (11.2)	14 (13.1)	0.676
Ascending and cecum	14 (13.1)	13 (12.1)	0.741
Treatment modality
ESD	45 (42.1)	42 (39.3)	0.676
EMR	62 (57.9)	65 (60.7)	0.676

¹Fisher’s exact test (excluding variable age);

²Student’s t-test. ESD: Endoscopic submucosal dissection; EMR: Endoscopic mucosal resection.

Table 2 Comparison of adverse events between antibiotic and control groups

	Antibiotic group(n = 107)	Control group(n = 107)	P value1
Clinical adverse events
Abdominal pain	3	16	0.002
Diarrhea	2	10	0.017
Hematochezia	4	6	0.517
Fever	1	9	0.010
Leukocytosis	2	12	0.006
Elevated CRP	2	8	0.050
Blood culture (+)	0	2	0.155
Hospital stay over 72 h	6	21	0.002

¹Fisher’s exact test. CRP: C-reactive protein.

Table 3 Relationship between the size of wound area and clinical adverse events

Wound area	< 10 mm × 10 mm	> 10 mm × 10 mm	P value3
	(n = 195)1	(n = 107)2
Clinical adverse events
Abdominal pain	12	16	0.009
Diarrhea	7	10	0.038
Hematochezia	3	6	0.048
Fever	3	9	0.004
Leukocytosis	3	12	0.003
Elevated CRP	2	8	0.003
Blood culture( + )	0	2	0.112

¹The follow-up outpatients;

²The control group inpatients;

³Fisher's exact test. CRP: C-reactive protein.