RAGE gene three polymorphisms with Crohn's disease susceptibility in Chinese Han population

Table 1 Characteristics of Crohn's disease patients and healthy controls in a Chinese Han population

Characteristics	CD patients	Control subjects
Number	312	479
Male/female	205/107	308/171
Age, mean ± SD (yr)	34.0 ± 13.0	36.5 ± 15.1
Age at diagnosis (ys)
< 17	42	63
17-40	212	324
> 40	58	92
CD behavior
Inflammatory	179
Stricturing	90
Penetrating	43
CD location
Ileum	194
Colon	27
Ileocolon	91
Perianal lesions
Yes	92
No	220
Appendectomy
Yes	18
No	294
Abdominal operation
Yes	72
No	240

CD: Crohn's disease.

Table 2 Genotype distributions and allele frequencies of the studied polymorphisms in patients and controls, and their risk prediction for Crohn's disease under three genetic models of inheritance

Polymorphism		Patients (n = 312)	Controls (n = 479)	P (χ2)	Genetic models	OR; 95%CI
rs1800624	TT	248	343		Additive	0.64; 0.47-0.88
	AT	62	123	0.012	Dominant	0.65; 0.46-0.91
	AA	2	13		Recessive	0.23; 0.05-1.03
	A	10.6%	15.6%	0.005
rs1800625	TT	228	353		Additive	0.98; 0.73-1.33
	CT	82	118	0.460	Dominant	1.03; 0.75-1.42
	CC	2	8		Recessive	0.38; 0.08-1.80
	C	13.8%	14.0%	0.940
rs2070600	GG	174	303		Additive	1.29; 1.03-1.62
	AG	112	148	0.086	Dominant	1.37; 1.02-1.83
	AA	26	28		Recessive	1.46; 0.84-2.55
	A	26.3%	21.3%	0.022

OR: Odds ratio.

Table 3 Haplotype frequencies of the studied polymorphisms in patients and controls, and their risk prediction for Crohn's disease

Haplotype	Case	Control	Hapscore	P value	Psim	OR	95%CI	P value
T-T-G	49.40%	49.10%	0.075	0.94	0.92	Reference
T-T-A	26.30%	21.30%	2.21	0.027	0.032	1.2	0.94-1.53	0.14
T-A-G	10.60%	15.60%	-2.82	0.005	0.002	0.67	0.49-0.94	0.018
C-T-G	13.80%	14.00%	-0.12	0.91	0.88	0.97	0.70-1.33	0.83

Alleles in haplotype were presented in order of polymorphisms rs1800625, rs1800624 and rs2070600. OR: Odds ratio; P_Sim: Simulated P.