Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats

Table 1 Effects on esophageal lesions, gastric secretion volume and acidity, oxidative variable in rats with gastroesophageal reflux

Groups	Doses (mg/kg)	ELI (mean ± SE)	I	Volume (mL)	I	Acidity (meq/L/100 g)	MDA (nmol/mg protein)	I	SH (mmol)	I
Negative control	-	0 ± 0c		0.1 ± 0c	--	120 ± 5.77b	1.76 ± 0.28b		0.56 ± 0.08b	--
Positive control	-	5.2 ± 0.33		2.69 ± 0.09	--	238 ± 19.37	2.56 ± 0.10		1.02 ± 0.05	--
D-002	25	3.36 ± 0.31b	35.4%	2.63 ± 0.36	2.3%	220 ± 22.57	2.05 ± 0.16a	64.0%	0.87 ± 0.06a	32.6%
D-002	100	2.90 ± 0.46b	44.2%	2.28 ± 0.45	19.0%	210 ± 19.79	1.98 ± 0.22a	72.5%	0.79 ± 0.08b	50.0%
D-002	200	2.8 ± 0.23b	46.1%	1.92 ± 0.25a	29.7%	233.7 ± 44.7	1.93 ± 0.22a	79.0%	0.77 ± 0.06a	54.3%
Omeprazole	10	2.54 ± 0.4b	51.1%	1.97 ± 0.14b	27.8%	158.5 ± 22.79a	1.87 ± 0.13b	86.3%	0.72 ± 0.05b	65.2%

These data were obtained from groups of 10 rats. Values are represented as mean ± SE.

^aP < 0.05,

^bP < 0.01 vs the positive control (Mann–Whitney U test). I: Inhibition; ELI: Esophageal lesions index; MDA: Malondialdehyde; SH: Sulfhydryl.