Kang HM, Kim GH, Park DY, Cheong HR, Baek DH, Lee BE, Song GA. Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics. World J Gastroenterol 2014; 20(42): 15771-15779 [PMID: 25400462 DOI: 10.3748/wjg.v20.i42.15771]
Corresponding Author of This Article
Gwang Ha Kim, MD, PhD, Department of Internal Medicine, Pusan National University School of Medicine, 1-10 Ami-dong, Seo-gu, Busan 602-739, South Korea. doc0224@pusan.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
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World J Gastroenterol. Nov 14, 2014; 20(42): 15771-15779 Published online Nov 14, 2014. doi: 10.3748/wjg.v20.i42.15771
Table 1 Baseline clinicopathologic characteristics of gastric epithelial dysplasias according to the morphologic type n (%)
Morphologic type
P value
Adenomatous
Hybrid
Foveolar
(n = 27)
(n = 15)
(n = 4)
Age (yr, mean ± SD)
59.4 ± 7.3
67.1 ± 9.0
64.3 ± 7.5
0.023
Sex
0.413
Male
16 (59)
9 (60)
4 (100)
Female
11 (41)
6 (40)
0 (0)
Tumor size (cm, mean ± SD)
1.3 ± 0.5
1.7 ± 1.1
1.9 ± 1.1
0.242
Location
0.251
Body/fundus
17 (63)
6 (40)
1 (25)
Antrum
10 (37)
9 (60)
3 (75)
Color
0.172
Discolored
13 (48)
3 (20)
1 (25)
Norma/reddish
14 (52)
12 (80)
3 (75)
Gross shape
0.328
Elevated/protruded
24 (89)
11 (73)
3 (75)
Flat/depressed
3 (11)
4 (27)
1 (25)
Histologic grade
0.328
Low
24 (89)
11 (73)
3 (75)
High
3 (11)
4 (27)
1 (25)
H. pylori infection
0.020
Present
23 (85)
7 (47)
2 (50)
Absent
4 (15)
8 (53)
2 (50)
Mucin phenotype
< 0.001
G-type
1 (4)
8 (53)
4 (100)
I-type
22 (82)
0 (0)
0 (0)
GI-type
2 (7)
6 (40)
0 (0)
N-type
2 (7)
1 (7)
0 (0)
Table 2 Magnifying endoscopy using narrow band imaging of gastric epithelial dysplasias according to the morphologic type n (%)
Morphologic type
P value
Adenomatous
Hybrid
Foveolar
(n = 27)
(n = 15)
(n = 4)
Microsurface pattern
< 0.001
Round pit
2 (7)
1 (7)
0 (0)
Tubular
15 (56)
2 (13)
0 (0)
Mixed
10 (37)
5 (33)
0 (0)
Papillary
0 (0)
5 (33)
4 (100)
Absent
0 (0)
2 (13)
0 (0)
Microvascular pattern
0.517
Regular
12 (44)
4 (27)
1 (25)
Irregular
15 (56)
11 (73)
3 (75)
Light blue crest
0.127
Present
14 (52)
5 (33)
0 (0)
Absent
13 (48)
10 (67)
4 (100)
White opaque substance
1
Present
9 (33)
5 (33)
1 (25)
Absent
18 (67)
10 (67)
3 (75)
Table 3 Mcrosurface and microvascular patterns according to mucin expression in gastric epithelial dysplasias n (%)
Microsurface pattern
P value
Microvasulcar pattern
P value
Round pit and/or tubular
Papillary
Absent
Regular
Irregular
(n = 35)
(n = 9)
(n = 2)
(n = 17)
(n = 29)
MUC2 expression
0.569
0.545
Negative (< 10%)
33 (94)
8 (89)
2 (100)
15 (88)
28 (97)
Positive (≥ 10%)
2 (6)
1 (11)
0 (0)
2 (12)
1 (3)
MUC5AC expression
0.001
0.301
Negative (< 10%)
26 (74)
1 (11)
1 (50)
12 (71)
16 (55)
Positive (≥ 10%)
9 (26)
8 (89)
1 (50)
5 (29)
13 (45)
MUC6 expression
0.014
0.149
Negative (< 10%)
28 (80)
3 (33)
1 (50)
14 (82)
18 (62)
Positive (≥ 10%)
7 (20)
6 (67)
1 (50)
3 (18)
11 (38)
CD10 expression
< 0.001
0.417
Negative (< 10%)
7 (20)
8 (89)
2 (100)
5 (29)
12 (41)
Positive (≥ 10%)
28 (80)
1 (11)
0 (0)
12 (71)
17 (59)
Table 4 Presence or absence of light blue crest and white opaque substance according to mucin expression in gastric epithelial dysplasias n (%)
Light blue crest
P value
White opaque substance
P value
Absent (n = 27)
Present (n = 19)
Absent (n = 31)
Present (n = 15)
MUC2 expression
1
1
Negative (< 10%)
25 (93)
18 (95)
29 (94)
14 (93)
Positive (≥ 10%)
2 (7)
1 (5)
2 (6)
1 (7)
MUC5AC expression
0.220
0.575
Negative (< 10%)
14 (52)
14 (74)
18 (58)
10 (67)
Positive (≥ 10%)
13 (48)
5 (26)
13 (42)
5 (33)
MUC6 expression
0.106
0.495
Negative (< 10%)
16 (59)
16 (84)
23 (74)
9 (60)
Positive (≥ 10%)
11 (41)
3 (16)
8 (26)
6 (40)
CD10 expression
0.002
0.723
Negative (< 10%)
15 (56)
2 (11)
12 (39)
5 (33)
Positive (≥ 10%)
12 (44)
17 (89)
19 (61)
10 (67)
Citation: Kang HM, Kim GH, Park DY, Cheong HR, Baek DH, Lee BE, Song GA. Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics. World J Gastroenterol 2014; 20(42): 15771-15779