Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers

Table 1 MUC1, MUC4 and MUC17 mucin and lectin expression scores

Patient group	MUC1		MUC4		MUC17		SNA		ECA
	Surface foveola cell	Gland cell	Surface foveola cell	Gland cell	Surface foveola cell	Gland cell	Surface foveola cell	Gland cell	Surface foveola cell	Gland cell
H. pylori+/NSAID-	2.93 ± 5.13	2.57 ± 4.50	2.79 ± 4.22	5.50 ± 3.14	11.05 ± 3.65	10.29 ± 4.67	2.00 ± 2.63	2.69 ± 4.01	13.27 ± 3.08	5.62 ± 4.37
	n = 28	n = 28	n = 14	n = 14	n = 21	n = 21	n = 16	n = 16	n = 26	n = 26
H. pylori-/NSAID+	0.00a± 0	0.00 ± 0	3.38 ± 3.07	3.54 ± 3.82	9.23 ± 3.64	9.57 ± 4.73	5.06 ± 5.52	3.44 ± 4.70	14.07 ± 2.01	4.47 ± 4.32
	n= 14	n = 14	n = 13	n = 13	n = 20	n = 20	n = 18	n = 18	n = 15	n = 15
H. pylori+/NSAID+	11.00 ± 3.78	7.33 ± 4.13	3.75 ± 2.93	6.44 ± 5.17	5.93 ± 2.99	8.80 ± 3.76	4.18 ± 5.57	6.94 ± 5.30	13.78 ± 2.73	4.61 ± 4.64
	n = 18	n = 18	n = 16	n = 16	n =19	n = 19	n = 17	n = 17	n = 18	n = 18
H. pylori-/NSAID-	9.89 ± 4.17	7.63 ± 4.60	4.59 ± 3.77	4.00 ± 4.12	6.93 ± 4.00	8.00 ± 3.48	6.17 ± 4.69	3.94 ± 5.45	13.06 ± 4.06	8.00 ± 5.15
	n = 19	n = 19	n = 17	n = 17	n =22	n = 22	n = 18	n = 18	n = 18	n = 18

^aP = 0.04, P < 0.0001, P < 0.0001 between Group 2 to Group 1, 3, and 4, respectively. ECA: Erythrina cristagalli agglutinin; H. pylori: Helicobacter pylori; NSAID: Non-steroidal anti-inflammatory drug; SNA: Sambucus nigra agglutinin.

Table 2 Comparison of mucin and sugar residues staining score between group 1 and group 4

Mucin/sugar	Group 1	n	Group 4	n	P value
MUC1 foveola	2.93 ± 5.13	28	9.89 ± 4.17	19	< 0.0001
MUC1 glands	2.57 ± 4.50	28	7.63 ± 4.60	19	< 0.0001
MUC4 foveola	2.79 ± 4.22	14	4.59 ± 3.77	17	0.221
MUC4 glands	5.50 ± 3.14	14	4.00 ± 4.12	17	0.286
MUC17 foveola	11.05 ± 3.65	21	6.93 ± 4.00	22	< 0.0001
MUC17 glands	10.29 ± 4.67	21	8.00 ± 3.48	22	< 0.0001
SNA foveola	2.00 ± 2.63	16	6.17 ± 4.69	18	0.004
SNA glands	2.69 ± 4.01	16	3.94 ± 5.45	18	0.457
ECA foveola	13.27 ± 3.08	26	13.06 ± 4.06	18	0.846
ECA glands	5.62 ± 4.37	26	8.00 ± 5.15	18	0.107

ECA: Erythrina cristagalli agglutinin; SNA: Sambucus nigra agglutinin.