Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B

Table 1 Performance of serum fibrosis markers for identification of significant fibrosis (≥ F2) and cirrhosis (F4) in patients with hepatitis B

Ref.	Year	Patients (n)	Diagnosis for≥F2				Diagnosis for F4
			Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)	Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)
Originally for patients with HCV
Fibrotest (includes α2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, and GGT)
Sebastiani et al[20]	2007	110	68	0.85	F2	81/90	20	0.76	F4	56/96
1Bottero et al[21]	2009	108	56	0.77	0.48	70/72	15	0.87	0.73	75/85
Forns index (includes age, platelet count, cholesterol, and GGT)
Sebastiani et al[20]	2007	110	68	0.63	4.20	58/78	20	-	-	-
Wong et al[22]	2010	156 +	75	0.70	5.20	28/91	26	-	-	-
		82	59	0.72	8.40	43/93	20
1Bottero et al[21]	2009	108	56	0.72	-	-	15	0.81	-	-
APRI (includes AST and platelet count)
Sebastiani et al[20]	2007	110	68	0.72	0.50	71/87	20	0.64	2.00	43/85
Kim et al[23]	2010	668	79	0.70	-	-	34	0.73	-	-
1Bottero et al[21]	2009	108	56	0.73	-	-	15	0.76	-	-
FIB-4 (includes age, AST, ALT, and platelet count)
Kim et al[23]	2010	668	79	0.86	1.00	91/73	34	0.93	1.60	88/84
1Bottero et al[21]	2009	108	56	0.74	-	-	15	0.80	-	-
Fibrometer (includes age, platelet count, PT index, AST, α2-macroglobulin, hyaluronate, and urea)
1Bottero et al[21]	2009	108	56	0.74	0.46	73/68	15	0.89	0.83	81/85
Originally for patients with HBV
Hui score (includes body mass index, bilirubin, albumin, and platelet count)
Hui et al[25]	2005	235	25	0.79	0.15	88/50	-	-	-	-
Zeng score (includes age, α2-macroglobulin, hyaluronate, and GGT)
Zeng et al[26]	2005	372	58	0.77	3.00	98/28	-	-	-	-

¹Study subjects were coinfected with human immunodeficiency virus. APRI: AST to platelet ratio index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AUROC: Area under the receiver operating characteristic curve; GGT: γ-Glutamyltranspeptidase; HBV: Hepatitis B virus; HCV: Hepatitis C virus; PT: Prothrombin.

Table 2 Performance of transient elastography for identification of significant fibrosis (≥ F2) and cirrhosis (F4) in patients with hepatitis B

Ref.	Year	Patients (n)	Diagnosis for≥F2				Diagnosis for F4
			Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)	Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)
Oliveri et al[39]	2008	188	26	0.97	7.5	94/88	20	0.97	11.8	86/96
Marcellin et al[40]	2009	173	50	0.81	7.2	70/83	8	0.93	11.0	93/87
Chan et al[41]	2009	161	-	-	-	-	25	0.93	12.0-13.42	98/75
Degos et al[32]	2010	284	42	0.78	5.2	89/38	10	0.85	12.9	52/93
Wong et al[22]	2010	156 + 82	68	0.80	9.0-12.02	54/99	23	-	-	-
1Miailhe et al[42]	2011	57	61	0.85	5.9	81/87	20	0.96	9.4	92/94

¹Study subjects were coinfected with human immunodeficiency virus;

²Adapted to ALT values. AUROC: Area under the receiver operating characteristic curve; Se: Sensitivity; Sp: Specificity.