Helicobacter pylori infection and drugs malabsorption

Table 1 Effects of cure of Helicobacter pylori infection on l-dopa absorption and/or symptoms scores in patients with Parkinson’s disease

Ref.	Study design (level of evidence)1	n	Helicobacter pylori positivity	Intervention	Outcome measure	Effect of eradicaction treatment
Benvenga et al[20]	Crossover study (4)	6	Serology	Eradication tx vs placebo	AUC of	21% increase after eradication treatment
					L-dopa	No variation after placebo
Pierantozzi et al[10]	RCT (1)	34	Serology, stool test, CP-test or culture	Eradication tx vs antioxidant tx (allopurinol)	AUC of	54% increase after eradication treatment
					L-dopa	No variation after antioxidant tx
Lee et al[11]	Case series (3)	65	Urea breath test	Eradication tx	UPDRS-III	No variation
					L-dopa "onset" and "on-time"	25.9% decrease and 11.9% increase after eradication tx

¹Levels of evidence based on the Oxford Centre for Evidence-Based Medicine. AUC: Area under the plasma concentration curve; Tx: Treatment.