Focus on alcoholic liver disease: From nosography to treatment

Table 1 Prognostic scoring systems in alcoholic hepatitis

Scoring system	Year	Formula
Maddrey DF (initial)[65]	1978	4.63 × PT (s) + serum bilirubin (mg/dL)
Maddrey DF (modified)[66]	1989	4.6 (patient’s PT - control PT) + serum bilirubin (mg/dL)
MELD (initial)[69]	2000	10 × [0.957 × loge(creatinine mg/dL) + 0.378 × loge(bilirubin mg/dL) +1.120 x loge(INR) + 0.643 × cause of cirrhosis1]
MELD (modified)[70]	2001	9.6 × loge(creatinine mg/dL) + 3.8 × loge(bilirubin mg/dL) +11.2 × loge(INR) + 6.4
GAHS[68]	2005	Score given2	1	2	3
		Age (yr)	< 50	≥ 50
		WCC	15 × 109/L	≥ 15 × 109/L
		Urea (mmol/L)	< 5	≥ 5
		INR	< 1.5	1.5-2	> 2
		Bilirubin (μmol/L)	125	125-250	> 250
Lille[72]	2007	3.19 - 0.101 × (age in years) + 0.147 × (albumin day 0 in g/L) + 0.0165 × (bilirubin day 1 in μmol/L - bilirubin day 7 in μmol/L) - (0.206 × renal insufficiency3) - 0.0065 × (bilirubin day 0 in μmol/L) - 0.0096 × PT (s)
ABIC[73]	2008	(age × 0.1) + (serum bilirubin × 0.08) + (serum creatinine × 0.3) + (INR × 0.8)

¹Cause of cirrhosis: 0 = alcohol or cholestasis; 1 = other etiology;

²GAHS: a score is given for each variable, producing a combined score of between 5 and 12;

³Renal insufficiency = 1 if creatinine ≥ 115 μmol/L; Renal insufficiency = 0 if creatinine < 115 μmol/L. DF: Discriminant Function; MELD: Model for End-Stage Liver Disease; GAHS: Glasgow alcoholic hepatitis score; ABIC: Age, bilirubin, INR and creatinine; PT: Prothrombin time; WCC: White cell count; INR: International normalized ratio.